The Bioinformatics Toolbox for CircRNA Discovery and Analysis

Overview

Journal Brief Bioinform

Publisher Oxford University Press

Specialty Biology

Date 2020 Feb 28

PMID 32103237

Citations 153

Authors

Liang Chen

Changliang Wang

Huiyan Sun

Juexin Wang

Yanchun Liang

Yan Wang

Garry Wong

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent advances in sequencing technologies and bioinformatics tools have led directly to an ever-expanding field of types and biological functions of circRNAs. In parallel with technological developments, practical applications of circRNAs have arisen including their utilization as biomarkers of human disease. Currently, circRNA-associated bioinformatics tools can support projects including circRNA annotation, circRNA identification and network analysis of competing endogenous RNA (ceRNA). In this review, we collected about 100 circRNA-associated bioinformatics tools and summarized their current attributes and capabilities. We also performed network analysis and text mining on circRNA tool publications in order to reveal trends in their ongoing development.

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