Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Feb 28

PMID 32102189

Citations 40

Authors

Zi-Run Tang

Xue-Ling Xu

Shou-Long Deng

Zheng-Xing Lian

Kun Yu

Affiliations

Soon will be listed here.

Abstract

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.

Citing Articles

The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review.

Drakaki E, Stavros S, Dedousi D, Potiris A, Mavrogianni D, Zikopoulos A J Clin Med. 2025; 13(24.

PMID: 39768492 PMC: 11728370. DOI: 10.3390/jcm13247568.

Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System.

Molinari F, Franco G, Tranchida N, Di Paola R, Cordaro M Int J Mol Sci. 2024; 25(23).

PMID: 39684250 PMC: 11641576. DOI: 10.3390/ijms252312540.

Bisphenol A Disrupts Ribosome Function during Ovarian Development of Mice.

Ma X, Wang Y, Li W, Wang K, Zhang S Toxics. 2024; 12(9).

PMID: 39330555 PMC: 11435667. DOI: 10.3390/toxics12090627.

Association of Maternal Air Pollution Exposure and Infant Lung Function Is Modified by Genetic Propensity to Oxidative Stress.

Vilcins D, Lee W, Pham C, Tanner S, Knibbs L, Burgner D Children (Basel). 2024; 11(8).

PMID: 39201872 PMC: 11352943. DOI: 10.3390/children11080937.

Endocrine-Disrupting Effects of Transplacental and Translactational Exposure to Tembotrione on Hormone Status in Wistar Rat Offspring at Different Developmental Stages: A Pilot Study.

Katic A, Karaconji I, Micek V, Zeljezic D Toxics. 2024; 12(8).

PMID: 39195635 PMC: 11359872. DOI: 10.3390/toxics12080533.

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