Bisphenol A (BPA) the Mighty and the Mutagenic

Overview

Journal Toxicol Rep

Date 2018 Jun 2

PMID 29854579

Citations 63

Authors

Nasir Jalal

Austin R Surendranath

Janak L Pathak

Shi Yu

Chang Y Chung

Affiliations

Soon will be listed here.

Abstract

Bisphenol A (BPA) is one of the most widely used synthetic compounds on the planet. Upon entering the diet, its highest concentration (1-104 ng/g of tissue) has been recorded in the placenta and fetus. This accumulation of BPA can have many health hazards ranging from the easy to repair single strand DNA breaks (SSBs) to error prone double strand DNA breaks (DSBs). Although the Human liver can efficiently metabolize BPA via glucuronidation and sulfation pathways, however the by-product Bisphenolquinone has been shown to act as a DNA adduct. Low doses of BPA have also been shown to interact with various signaling pathways to disrupt normal downstream signaling. Analysis has been made on how BPA could interact with several signaling pathways such as NFκB, JNK, MAPK, ER and AR that eventually lead to disease morphology and even tumorigenesis. The role of low dose BPA is also discussed in dysregulating Ca homeostasis of the cell by inhibiting calcium channels such as SPCA1/2 to suggest a new direction for future research in the realms of BPA induced disease morphology and mutagenicity.

Citing Articles

The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review.

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PMID: 39768492 PMC: 11728370. DOI: 10.3390/jcm13247568.

Comparative study of cytotoxic Signaling pathways in H1299 cells exposed to alternative Bisphenols: BPA, BPF, and BPS.

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A pilot study: relationship between Bisphenol A, Bisphenol-glucuronide and total 25 hydroxy vitamin D in maternal-child pairs in a South African population.

Gounden V, Naidoo R, Chuturgoon A Front Endocrinol (Lausanne). 2024; 15:1108969.

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Integrative transcriptomic profiling uncovers immune and functional responses to bisphenol a across multiple tissues in male mice.

Park Y, Jang M, Ryu D, Lim B, Pathak R, Pang M Anim Cells Syst (Seoul). 2024; 28(1):519-535.

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Turn-off fluorescent nanoprobe based on carbon dots synthesised by UV/HO advanced oxidation for the detection of bisphenol A in canned foods.

Abalde-Pujales A, Lavilla I, Bendicho C, Romero V Mikrochim Acta. 2024; 191(11):695.

PMID: 39441371 DOI: 10.1007/s00604-024-06784-5.

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