Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco

Overview

Journal Environ Sci Technol

Publisher American Chemical Society

Specialty Environmental Health

Date 2020 Feb 27

PMID 32100527

Citations 37

Authors

Jessica Trowbridge

Roy R Gerona

Thomas Lin

Ruthann A Rudel

Vincent Bessonneau

Heather Buren

Rachel Morello-Frosch

Affiliations

Soon will be listed here.

Abstract

Studies of firefighters have shown increased exposures to carcinogenic compounds and elevated rates of certain cancers compared to the general population, yet this research has focused almost exclusively on men. To address this gap, the Women Firefighters Biomonitoring Collaborative created a biological sample archive and analyzed levels of perfluoroalkyl substances (PFAS) among women firefighters ( = 86) and office workers ( = 84) in San Francisco. Serum samples were collected and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure and compare PFAS levels between firefighters and office workers. 7 of 12 PFAS congeners were detected in the least 70% of the study population, and 4 congeners were detected in 100% of participants. In regression models comparing PFAS levels by occupation and adjusting for potential confounders, firefighters had higher geometric mean concentrations of PFAS compared to office workers PFHxS (2.22 (95% CI = 1.55, 3.18)), PFUnDA (1.83 (95% CI = 0.97, 3.45)), and PFNA (1.26 (95% CI = 1.01, 1.58)). Among firefighters, occupational position predicted exposure-firefighters and officers had higher PFNA, PFOA, PFDA, and PFUnDA levels compared to drivers. Women firefighters are exposed to higher levels of some PFAS compared to office workers, suggesting that some of these exposures may be occupationally related.

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References

Liu S, Yang R, Yin N, Faiola F . The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation. J Environ Sci (China). 2019; 88:187-199. DOI: 10.1016/j.jes.2019.08.016. View

Olsen G, Burris J, Ehresman D, Froehlich J, Seacat A, Butenhoff J . Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect. 2007; 115(9):1298-305. PMC: 1964923. DOI: 10.1289/ehp.10009. View

Olsen G, Chang S, Noker P, Gorman G, Ehresman D, Lieder P . A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans. Toxicology. 2008; 256(1-2):65-74. DOI: 10.1016/j.tox.2008.11.008. View

Scheringer M, Trier X, Cousins I, de Voogt P, Fletcher T, Wang Z . Helsingør statement on poly- and perfluorinated alkyl substances (PFASs). Chemosphere. 2014; 114:337-9. DOI: 10.1016/j.chemosphere.2014.05.044. View

Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J . Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut. 2019; 247:1055-1063. PMC: 6404528. DOI: 10.1016/j.envpol.2019.01.064. View

Fent K, Evans D, Babik K, Striley C, Bertke S, Kerber S . Airborne contaminants during controlled residential fires. J Occup Environ Hyg. 2018; 15(5):399-412. DOI: 10.1080/15459624.2018.1445260. View

Gainey S, Horn G, Towers A, Oelschlager M, Tir V, Drnevich J . Exposure to a firefighting overhaul environment without respiratory protection increases immune dysregulation and lung disease risk. PLoS One. 2018; 13(8):e0201830. PMC: 6103500. DOI: 10.1371/journal.pone.0201830. View

Brandt-Rauf P, Fallon Jr L, Tarantini T, Idema C, Andrews L . Health hazards of fire fighters: exposure assessment. Br J Ind Med. 1988; 45(9):606-12. PMC: 1009663. DOI: 10.1136/oem.45.9.606. View

Brown F, Whitehead T, Park J, Metayer C, Petreas M . Levels of non-polybrominated diphenyl ether brominated flame retardants in residential house dust samples and fire station dust samples in California. Environ Res. 2014; 135:9-14. PMC: 4262617. DOI: 10.1016/j.envres.2014.08.022. View

10.

Laitinen J, Koponen J, Koikkalainen J, Kiviranta H . Firefighters' exposure to perfluoroalkyl acids and 2-butoxyethanol present in firefighting foams. Toxicol Lett. 2014; 231(2):227-32. DOI: 10.1016/j.toxlet.2014.09.007. View

11.

Adetona O, Zhang J, Hall D, Wang J, Vena J, Naeher L . Occupational exposure to woodsmoke and oxidative stress in wildland firefighters. Sci Total Environ. 2013; 449:269-75. DOI: 10.1016/j.scitotenv.2013.01.075. View

12.

Caux C, OBrien C, Viau C . Determination of firefighter exposure to polycyclic aromatic hydrocarbons and benzene during fire fighting using measurement of biological indicators. Appl Occup Environ Hyg. 2002; 17(5):379-86. DOI: 10.1080/10473220252864987. View

13.

Boronow K, Brody J, Schaider L, Peaslee G, Havas L, Cohn B . Serum concentrations of PFASs and exposure-related behaviors in African American and non-Hispanic white women. J Expo Sci Environ Epidemiol. 2019; 29(2):206-217. PMC: 6380931. DOI: 10.1038/s41370-018-0109-y. View

14.

McCullagh M, Rosemberg M . Social Desirability Bias in Self-Reporting of Hearing Protector Use among Farm Operators. Ann Occup Hyg. 2015; 59(9):1200-7. PMC: 4643611. DOI: 10.1093/annhyg/mev046. View

15.

Austin C, Wang D, ECOBICHON D, Dussault G . Characterization of volatile organic compounds in smoke at experimental fires. J Toxicol Environ Health A. 2001; 63(3):191-206. DOI: 10.1080/15287390151101547. View

16.

Harada K, Inoue K, Morikawa A, Yoshinaga T, Saito N, Koizumi A . Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion. Environ Res. 2005; 99(2):253-61. DOI: 10.1016/j.envres.2004.12.003. View

17.

Delahunt B, Bethwaite P, Nacey J . Occupational risk for renal cell carcinoma. A case-control study based on the New Zealand Cancer Registry. Br J Urol. 1995; 75(5):578-82. DOI: 10.1111/j.1464-410x.1995.tb07410.x. View

18.

Shen B, Whitehead T, McNeel S, Brown F, Dhaliwal J, Das R . High levels of polybrominated diphenyl ethers in vacuum cleaner dust from California fire stations. Environ Sci Technol. 2015; 49(8):4988-94. DOI: 10.1021/es505463g. View

19.

Post G, Gleason J, Cooper K . Key scientific issues in developing drinking water guidelines for perfluoroalkyl acids: Contaminants of emerging concern. PLoS Biol. 2017; 15(12):e2002855. PMC: 5737881. DOI: 10.1371/journal.pbio.2002855. View

20.

Barry V, Winquist A, Steenland K . Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Environ Health Perspect. 2013; 121(11-12):1313-8. PMC: 3855514. DOI: 10.1289/ehp.1306615. View