Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran

Overview

Journal J Ophthalmic Vis Res

Specialty Ophthalmology

Date 2020 Feb 26

PMID 32095208

Citations 5

Authors

Ali Yousefian

Saeed Shokoohi-Rad

Mohammad Reza Abbaszadegan

Dorsa Morshedi Rad

Selma Zargari

Saman Milanizadeh

Negar Morovatdar

Ramin Daneshvar

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population.

Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method.

Results: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 5.7 years were selected for evaluation. There was a significant association between rs3816415 ( = 0.005), rs736893 ( 0.001), rs7494379 ( 0.001), and rs1258267 ( = 0.02) with PACG susceptibility. This association could not be shown for rs3739821.

Conclusion: It was revealed that studied variants in and genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate .

Citing Articles

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