Exosomal MiRNAs: Novel Players in Viral Infection

Overview

Journal Epigenomics

Specialty Genetics

Date 2020 Feb 26

PMID 32093516

Citations 27

Authors

Javid Sadri Nahand

Maryam Mahjoubin-Tehran

Mohsen Moghoofei

Mohammad Hossein Pourhanifeh

Hamid Reza Mirzaei

Zatollah Asemi

Alireza Khatami

Farah Bokharaei-Salim

Hamed Mirzaei

Michael R Hamblin

Affiliations

Soon will be listed here.

Abstract

Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

Citing Articles

MicroRNA as Key Players in Hepatocellular Carcinoma: Insights into Their Role in Metastasis.

Saadh M, Hussain Q, Alazzawi T, Fahdil A, Athab Z, Yarmukhamedov B Biochem Genet. 2024; .

PMID: 39103713 DOI: 10.1007/s10528-024-10897-0.

Parkinson's Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells.

Saadh M, Faisal A, Adil M, Zabibah R, Mamadaliev A, Jawad M Mol Neurobiol. 2024; 61(11):8552-8574.

PMID: 38520611 DOI: 10.1007/s12035-024-04111-w.

Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.

Chang H, Chen E, Hu Y, Wu L, Deng L, Ye-Lehmann S Adv Sci (Weinh). 2023; 11(10):e2305554.

PMID: 38143270 PMC: 10933635. DOI: 10.1002/advs.202305554.

MicroRNAs: Small but Key Players in Viral Infections and Immune Responses to Viral Pathogens.

Bauer A, Majumdar N, Williams F, Rajput S, Pokhrel L, Cook P Biology (Basel). 2023; 12(10).

PMID: 37887044 PMC: 10604607. DOI: 10.3390/biology12101334.

The role of extracellular vesicle-derived miRNAs in adipose tissue function and metabolic health.

Paneru B, Hill D Immunometabolism (Cobham). 2023; 5(3):e00027.

PMID: 37501663 PMC: 10371064. DOI: 10.1097/IN9.0000000000000027.

References

Sonnino S, Prinetti A, Mauri L, Chigorno V, Tettamanti G . Dynamic and structural properties of sphingolipids as driving forces for the formation of membrane domains. Chem Rev. 2006; 106(6):2111-25. DOI: 10.1021/cr0100446. View

Kim J, Lee C, Lee S . Exosomal Transmission of MicroRNA from HCV Replicating Cells Stimulates Transdifferentiation in Hepatic Stellate Cells. Mol Ther Nucleic Acids. 2019; 14:483-497. PMC: 6369229. DOI: 10.1016/j.omtn.2019.01.006. View

Pachler K, Ketterl N, Desgeorges A, Dunai Z, Laner-Plamberger S, Streif D . An In Vitro Potency Assay for Monitoring the Immunomodulatory Potential of Stromal Cell-Derived Extracellular Vesicles. Int J Mol Sci. 2017; 18(7). PMC: 5535905. DOI: 10.3390/ijms18071413. View

Xin H, Wang F, Li Y, Lu Q, Cheung W, Zhang Y . Secondary Release of Exosomes From Astrocytes Contributes to the Increase in Neural Plasticity and Improvement of Functional Recovery After Stroke in Rats Treated With Exosomes Harvested From MicroRNA 133b-Overexpressing Multipotent Mesenchymal.... Cell Transplant. 2016; 26(2):243-257. PMC: 5303172. DOI: 10.3727/096368916X693031. View

Rappa G, Mercapide J, Anzanello F, Pope R, Lorico A . Biochemical and biological characterization of exosomes containing prominin-1/CD133. Mol Cancer. 2013; 12:62. PMC: 3698112. DOI: 10.1186/1476-4598-12-62. View

Knowles W, Pipkin P, Andrews N, Vyse A, Minor P, Brown D . Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol. 2003; 71(1):115-23. DOI: 10.1002/jmv.10450. View

Nuovo G, Garofalo M, Valeri N, Roulstone V, Volinia S, Cohn D . Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples. Mod Pathol. 2012; 25(10):1333-44. PMC: 4275064. DOI: 10.1038/modpathol.2012.95. View

Neerukonda S, Tavlarides-Hontz P, McCarthy F, Pendarvis K, Parcells M . Comparison of the Transcriptomes and Proteomes of Serum Exosomes from Marek's Disease Virus-Vaccinated and Protected and Lymphoma-Bearing Chickens. Genes (Basel). 2019; 10(2). PMC: 6410298. DOI: 10.3390/genes10020116. View

Choi H, Lee S . TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-FU. Arch Virol. 2016; 162(2):369-377. DOI: 10.1007/s00705-016-3109-z. View

10.

Janas T, Janas T . The selection of aptamers specific for membrane molecular targets. Cell Mol Biol Lett. 2010; 16(1):25-39. PMC: 6275783. DOI: 10.2478/s11658-010-0023-3. View

11.

Kim V, Han J, Siomi M . Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009; 10(2):126-39. DOI: 10.1038/nrm2632. View

12.

Hirsch H, Brennan D, Drachenberg C, Ginevri F, Gordon J, Limaye A . Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation. 2005; 79(10):1277-86. DOI: 10.1097/01.tp.0000156165.83160.09. View

13.

Xin H, Li Y, Cui Y, Yang J, Zhang Z, Chopp M . Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab. 2013; 33(11):1711-5. PMC: 3824189. DOI: 10.1038/jcbfm.2013.152. View

14.

Volinia S, Galasso M, Sana M, Wise T, Palatini J, Huebner K . Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A. 2012; 109(8):3024-9. PMC: 3286983. DOI: 10.1073/pnas.1200010109. View

15.

Hosseini S, Taghiyar L, Safari F, Baghaban Eslaminejad M . Regenerative Medicine Applications of Mesenchymal Stem Cells. Adv Exp Med Biol. 2018; 1089:115-141. DOI: 10.1007/5584_2018_213. View

16.

Batagov A, Kurochkin I . Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3'-untranslated regions. Biol Direct. 2013; 8:12. PMC: 3732077. DOI: 10.1186/1745-6150-8-12. View

17.

Plaisance-Bonstaff K, Renne R . Viral miRNAs. Methods Mol Biol. 2011; 721:43-66. DOI: 10.1007/978-1-61779-037-9_3. View

18.

Gibbings D, Ciaudo C, Erhardt M, Voinnet O . Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol. 2009; 11(9):1143-9. DOI: 10.1038/ncb1929. View

19.

Kajimoto T, Okada T, Miya S, Zhang L, Nakamura S . Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. Nat Commun. 2013; 4:2712. DOI: 10.1038/ncomms3712. View

20.

Bernard M, Zhao H, Yue S, Anandaiah A, Koziel H, Tachado S . Novel HIV-1 miRNAs stimulate TNFα release in human macrophages via TLR8 signaling pathway. PLoS One. 2014; 9(9):e106006. PMC: 4156304. DOI: 10.1371/journal.pone.0106006. View