Refining Cancer Management Using Integrated Liquid Biopsy

Overview

Journal Theranostics

Date 2020 Feb 25

PMID 32089746

Citations 23

Authors

Juhui Qiu

Jianxiong Xu

Kang Zhang

Wei Gu

Liming Nie

Guixue Wang

Yang Luo

Affiliations

Soon will be listed here.

Abstract

Liquid biopsy has emerged in the last ten years as an appealing noninvasive strategy to support early cancer diagnosis and follow-up interventions. However, conventional liquid biopsy strategies involving specified biomarkers have encountered unexpected inconsistencies stemming from the use of different analytical methodologies. Recent reports have repeatedly demonstrated that integrated detection of multiple liquid biopsy biomarkers can significantly improve diagnostic performance by eliminating the influence of intratumoral heterogeneity. Herein, we review the progress in the field of liquid biopsy and propose a novel integrated liquid biopsy framework consisting of three categories: elementary, intermediate, and advanced integration. We also summarize the merits of the integration strategy and propose a roadmap toward refining cancer diagnosis, metastasis surveillance, and prognostication.

Citing Articles

Assessment of salivary microRNA by RT-qPCR: Facing challenges in data interpretation for clinical diagnosis.

Van Der Hofstadt M, Cardinal A, Lepeltier M, Boulestreau J, Ouedraogo A, Kahli M PLoS One. 2024; 19(12):e0314733.

PMID: 39656703 PMC: 11630609. DOI: 10.1371/journal.pone.0314733.

Liquid biopsy in cancer current: status, challenges and future prospects.

Ma L, Guo H, Zhao Y, Liu Z, Wang C, Bu J Signal Transduct Target Ther. 2024; 9(1):336.

PMID: 39617822 PMC: 11609310. DOI: 10.1038/s41392-024-02021-w.

Identification of Autophagy-Related Biomarkers and Diagnostic Model in Alzheimer's Disease.

Xu W, Su X, Qin J, Jin Y, Zhang N, Huang S Genes (Basel). 2024; 15(8).

PMID: 39202387 PMC: 11354206. DOI: 10.3390/genes15081027.

Advances in liquid biopsy in neuroblastoma.

Zhuo Z, Lin L, Miao L, Li M, He J Fundam Res. 2024; 2(6):903-917.

PMID: 38933377 PMC: 11197818. DOI: 10.1016/j.fmre.2022.08.005.

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications.

Salu P, Reindl K Cancers (Basel). 2024; 16(6).

PMID: 38539545 PMC: 10969710. DOI: 10.3390/cancers16061213.

References

Nagaiah G, Abraham J . Circulating tumor cells in the management of breast cancer. Clin Breast Cancer. 2010; 10(3):209-16. DOI: 10.3816/CBC.2010.n.028. View

Liu H, Xu Y, Xiang J, Long L, Green S, Yang Z . Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer. Clin Cancer Res. 2016; 23(2):478-488. DOI: 10.1158/1078-0432.CCR-16-1203. View

Kerr B, McCabe N, Feng W, Byzova T . Platelets govern pre-metastatic tumor communication to bone. Oncogene. 2012; 32(36):4319-24. PMC: 3687027. DOI: 10.1038/onc.2012.447. View

Kang S, Li Q, Chen Q, Zhou Y, Park S, Lee G . CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol. 2017; 18(1):53. PMC: 5364586. DOI: 10.1186/s13059-017-1191-5. View

Manier S, Liu C, Avet-Loiseau H, Park J, Shi J, Campigotto F . Prognostic role of circulating exosomal miRNAs in multiple myeloma. Blood. 2017; 129(17):2429-2436. PMC: 5409448. DOI: 10.1182/blood-2016-09-742296. View

Abbosh C, Birkbak N, Wilson G, Jamal-Hanjani M, Constantin T, Salari R . Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature. 2017; 545(7655):446-451. PMC: 5812436. DOI: 10.1038/nature22364. View

Guo S, Diep D, Plongthongkum N, Fung H, Zhang K, Zhang K . Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet. 2017; 49(4):635-642. PMC: 5374016. DOI: 10.1038/ng.3805. View

Dewey F, Gusarova V, ODushlaine C, Gottesman O, Trejos J, Hunt C . Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. N Engl J Med. 2016; 374(12):1123-33. PMC: 4900689. DOI: 10.1056/NEJMoa1510926. View

Dhar M, Lam J, Walser T, Dubinett S, Rettig M, Di Carlo D . Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay. Proc Natl Acad Sci U S A. 2018; 115(40):9986-9991. PMC: 6176626. DOI: 10.1073/pnas.1803884115. View

10.

Best M, Sol N, In t Veld S, Vancura A, Muller M, Niemeijer A . Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets. Cancer Cell. 2017; 32(2):238-252.e9. PMC: 6381325. DOI: 10.1016/j.ccell.2017.07.004. View

11.

Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008; 10(12):1470-6. PMC: 3423894. DOI: 10.1038/ncb1800. View

12.

Challagundla K, Wise P, Neviani P, Chava H, Murtadha M, Xu T . Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015; 107(7). PMC: 4651042. DOI: 10.1093/jnci/djv135. View

13.

Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L . Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015; 11(1):e1004898. PMC: 4287352. DOI: 10.1371/journal.pgen.1004898. View

14.

Yi X, Ma J, Guan Y, Chen R, Yang L, Xia X . The feasibility of using mutation detection in ctDNA to assess tumor dynamics. Int J Cancer. 2017; 140(12):2642-2647. PMC: 5434851. DOI: 10.1002/ijc.30620. View

15.

Krug A, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A . Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma. Ann Oncol. 2017; 29(3):700-706. PMC: 5889041. DOI: 10.1093/annonc/mdx765. View

16.

Liang W, Zhao Y, Huang W, Gao Y, Xu W, Tao J . Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA). Theranostics. 2019; 9(7):2056-2070. PMC: 6485294. DOI: 10.7150/thno.28119. View

17.

Chen M, Whisler J, Frose J, Yu C, Shin Y, Kamm R . On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics. Nat Protoc. 2017; 12(5):865-880. PMC: 5509465. DOI: 10.1038/nprot.2017.018. View

18.

Jansen F, van Schaik R, Kurstjens J, Horninger W, Klocker H, Bektic J . Prostate-specific antigen (PSA) isoform p2PSA in combination with total PSA and free PSA improves diagnostic accuracy in prostate cancer detection. Eur Urol. 2010; 57(6):921-7. DOI: 10.1016/j.eururo.2010.02.003. View

19.

Cohen J, Javed A, Thoburn C, Wong F, Tie J, Gibbs P . Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proc Natl Acad Sci U S A. 2017; 114(38):10202-10207. PMC: 5617273. DOI: 10.1073/pnas.1704961114. View

20.

Ng S, Bahig H, Wang J, Cardenas C, Lucci A, Hall C . Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching 'liquid biopsy' and quantitative tumor modeling. BMC Cancer. 2018; 18(1):903. PMC: 6148797. DOI: 10.1186/s12885-018-4808-5. View