Striatal Dopamine Responses to Feeding Are Altered in People with Obesity

Overview

Journal Obesity (Silver Spring)

Specialties Endocrinology
Nutritional Sciences
Physiology

Date 2020 Feb 23

PMID 32086877

Citations 1

Authors

Sarah A Eisenstein

Kevin J Black

Amjad Samara

Jonathan M Koller

Julia P Dunn

Tamara Hershey

Samuel Klein

Gordon I Smith

Affiliations

Soon will be listed here.

Abstract

Objective: This study determined whether striatal dopamine (DA) release is affected by food ingestion and whether the DA response to high-calorie food images is greater in the fasted than in the fed state in people with obesity.

Methods: Striatal DA release was evaluated in 10 people with obesity and prediabetes after consuming a meal to satiation and after fasting overnight as well as in response to viewing images of high-calorie compared with low-calorie foods after consuming a meal to satiation or fasting overnight by using positron emission tomography with [ C]raclopride injection.

Results: Striatal DA D2/D3 receptor availability was not different during fasted and fed conditions. Viewing images of high-calorie foods induced striatal DA release relative to viewing images of low-calorie foods (P < 0.05), but there was no difference in the magnitude of the response between fasting and fed conditions.

Conclusions: People with obesity and prediabetes do not increase striatal DA release after eating a meal to satiation compared with fasting overnight and fail to inhibit DA release in response to high-calorie food stimuli after eating a meal to satiation. These data suggest that impaired DA signaling contributes to greater energy intake during meals in this population.

Citing Articles

Brain dopamine responses to ultra-processed milkshakes are highly variable and not significantly related to adiposity in humans.

Darcey V, Guo J, Chi M, Chung S, Courville A, Gallagher I medRxiv. 2024; .

PMID: 39108535 PMC: 11302720. DOI: 10.1101/2024.06.24.24309440.

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