An Alpha-defensin Gene Single Nucleotide Polymorphism Modulates the Gut Microbiota and May Alter the Risk of Acute Graft-versus-host Disease

Overview

Journal Br J Haematol

Specialty Hematology

Date 2020 Feb 23

PMID 32086815

Citations 2

Authors

Armin Rashidi

Adam Herman

Antonio L C Gomes

Jonathan U Peled

Robert R Jenq

Daniel G Brereton

Christopher Staley

Bruce R Blazar

Daniel J Weisdorf

Affiliations

Soon will be listed here.

Abstract

We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri-engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II-IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28-1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.

Citing Articles

Multifaceted involvements of Paneth cells in various diseases within intestine and systemically.

Cui C, Wang X, Li L, Wei H, Peng J Front Immunol. 2023; 14:1115552.

PMID: 36993974 PMC: 10040535. DOI: 10.3389/fimmu.2023.1115552.

Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression.

Chen J, Zhang S, Feng X, Wu Z, Dubois W, Thovarai V Int J Mol Sci. 2020; 21(17).

PMID: 32858886 PMC: 7503692. DOI: 10.3390/ijms21176143.

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