Commentary on the Study of Roy Et Al. Amygdala Based Altered Mir-128-3p in Conferring Susceptibility to Depression-like Behavior Via Wnt Signalling

Overview

Journal Int J Neuropsychopharmacol

Publisher Oxford University Press

Specialty Psychiatry

Date 2020 Feb 20

PMID 32072167

Citations 4

Authors

Gianluca Serafini

Alice Trabucco

Andrea Amerio

Andrea Aguglia

Mario Amore

Affiliations

Soon will be listed here.

Abstract

The study of Roy and colleagues recently accepted for publication in International Journal of Neuropsychopharmacology is a very interesting report investigating the role of specific microRNAs (miRNAs) in vulnerability or resistance to major depressive disorder in a specific brain region (e.g., amygdala). MiRNAs may act as a mega-controller of gene expression being involved in the pathogenesis of major neuropsychiatric conditions. Interestingly, some of the altered miRNAs (e.g., hsa-miR-425-3p, miR-425, miR-674-3p, and miR-873-3p) identified in this study were found to be dysregulated even in existing studies, but several methodological issues may hamper the translation of basic research findings in clinical studies. MiRNAs are proposed as possible biomarkers of disease and treatment response to disentangle the biological complexity underlying major affective disorders. The main implications regarding the present findings are discussed.

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References

Lopez J, Fiori L, Gross J, Labonte B, Yerko V, Mechawar N . Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers. Int J Neuropsychopharmacol. 2013; 17(1):23-32. DOI: 10.1017/S1461145713000941. View

Serafini G, Pompili M, Hansen K, Obrietan K, Dwivedi Y, Shomron N . The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. Cell Mol Neurobiol. 2013; 34(1):17-30. PMC: 11488878. DOI: 10.1007/s10571-013-9997-5. View

Fiori L, Lopez J, Richard-Devantoy S, Berlim M, Chachamovich E, Jollant F . Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response. Int J Neuropsychopharmacol. 2017; 20(8):619-623. PMC: 5570004. DOI: 10.1093/ijnp/pyx034. View

Fang Y, Qiu Q, Zhang S, Sun L, Li G, Xiao S . Changes in miRNA-132 and miR-124 levels in non-treated and citalopram-treated patients with depression. J Affect Disord. 2018; 227:745-751. DOI: 10.1016/j.jad.2017.11.090. View

Balakathiresan N, Chandran R, Bhomia M, Jia M, Li H, Maheshwari R . Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential. J Psychiatr Res. 2014; 57:65-73. DOI: 10.1016/j.jpsychires.2014.05.020. View

Serafini G, Pompili M, Innamorati M, Giordano G, Montebovi F, Sher L . The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior. Neurosci Res. 2012; 73(3):179-90. DOI: 10.1016/j.neures.2012.04.001. View

Bartel D . MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2):215-33. PMC: 3794896. DOI: 10.1016/j.cell.2009.01.002. View

Maffioletti E, Cattaneo A, Rosso G, Maina G, Maj C, Gennarelli M . Peripheral whole blood microRNA alterations in major depression and bipolar disorder. J Affect Disord. 2016; 200:250-8. DOI: 10.1016/j.jad.2016.04.021. View

Roy B, Dunbar M, Agrawal J, Allen L, Dwivedi Y . Amygdala-Based Altered miRNome and Epigenetic Contribution of miR-128-3p in Conferring Susceptibility to Depression-Like Behavior via Wnt Signaling. Int J Neuropsychopharmacol. 2020; 23(3):165-177. PMC: 7171932. DOI: 10.1093/ijnp/pyz071. View

10.

Dwivedi Y . Pathogenetic and therapeutic applications of microRNAs in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 64:341-8. PMC: 4537399. DOI: 10.1016/j.pnpbp.2015.02.003. View

11.

Ciani L, Krylova O, Smalley M, Dale T, Salinas P . A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol. 2004; 164(2):243-53. PMC: 2172322. DOI: 10.1083/jcb.200309096. View

12.

Dwivedi Y . MicroRNAs in depression and suicide: Recent insights and future perspectives. J Affect Disord. 2018; 240:146-154. PMC: 6108934. DOI: 10.1016/j.jad.2018.07.075. View