Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2020 Feb 19

PMID 32067051

Citations 48

Authors

Riann Jenay Egusquiza

Bruce Blumberg

Affiliations

Soon will be listed here.

Abstract

The incidence of obesity has reached an all-time high, and this increase is observed worldwide. There is a growing need to understand all the factors that contribute to obesity to effectively treat and prevent it and associated comorbidities. The obesogen hypothesis proposes that there are chemicals in our environment termed obesogens that can affect individual susceptibility to obesity and thus help explain the recent large increases in obesity. This review discusses current advances in our understanding of how obesogens act to affect health and obesity susceptibility. Newly discovered obesogens and potential obesogens are discussed, together with future directions for research that may help to reduce the impact of these pervasive chemicals.

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References

Ludwig D, Ebbeling C . The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out". JAMA Intern Med. 2018; 178(8):1098-1103. PMC: 6082688. DOI: 10.1001/jamainternmed.2018.2933. View

Guo H, Yan H, Cheng D, Wei X, Kou R, Si J . Tributyltin exposure induces gut microbiome dysbiosis with increased body weight gain and dyslipidemia in mice. Environ Toxicol Pharmacol. 2018; 60:202-208. DOI: 10.1016/j.etap.2018.04.020. View

Foley B, Doheny D, Black M, Pendse S, Wetmore B, Clewell R . Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis. Toxicol Sci. 2016; 155(1):85-100. PMC: 5216650. DOI: 10.1093/toxsci/kfw186. View

le Maire A, Grimaldi M, Roecklin D, Dagnino S, Vivat-Hannah V, Balaguer P . Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 2009; 10(4):367-73. PMC: 2672886. DOI: 10.1038/embor.2009.8. View

Attina T, Hauser R, Sathyanarayana S, Hunt P, Bourguignon J, Myers J . Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol. 2016; 4(12):996-1003. DOI: 10.1016/S2213-8587(16)30275-3. View

Alonso-Magdalena P, Garcia-Arevalo M, Quesada I, Nadal A . Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life. Endocrinology. 2015; 156(5):1659-70. DOI: 10.1210/en.2014-1952. View

Sun Z, Yang X, Liu Q, Li C, Zhou Q, Fiedler H . Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells. J Hazard Mater. 2019; 379:120794. DOI: 10.1016/j.jhazmat.2019.120794. View

Ravelli G, Stein Z, SUSSER M . Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976; 295(7):349-53. DOI: 10.1056/NEJM197608122950701. View

Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J . Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol Pharmacol. 2004; 67(3):766-74. DOI: 10.1124/mol.104.008409. View

10.

Chu P, Lin L, Chen P, Su T, Lin C . Negative association between acrylamide exposure and body composition in adults: NHANES, 2003-2004. Nutr Diabetes. 2017; 7(3):e246. PMC: 5380889. DOI: 10.1038/nutd.2016.48. View

11.

Qin Y, Roberts J, Grimm S, Lih F, Deterding L, Li R . An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol. 2018; 19(1):7. PMC: 5782396. DOI: 10.1186/s13059-018-1389-1. View

12.

Temkin A, Bowers R, Magaletta M, Holshouser S, Maggi A, Ciana P . Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen. Environ Health Perspect. 2015; 124(1):112-9. PMC: 4710608. DOI: 10.1289/ehp.1409672. View

13.

Brown R, Sharma A, Ardern C, Mirdamadi P, Mirdamadi P, Kuk J . Secular differences in the association between caloric intake, macronutrient intake, and physical activity with obesity. Obes Res Clin Pract. 2015; 10(3):243-55. DOI: 10.1016/j.orcp.2015.08.007. View

14.

Kuznetsova T, Wang S, Rao N, Mandoli A, Martens J, Rother N . Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization. Genome Biol. 2015; 16:264. PMC: 4665721. DOI: 10.1186/s13059-015-0832-9. View

15.

Zhang J, Sun P, Yang F, Kong T, Zhang R . Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus). Chemosphere. 2016; 152:221-8. DOI: 10.1016/j.chemosphere.2016.02.127. View

16.

Dou H, Duan Y, Zhang X, Yu Q, Di Q, Song Y . Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation. J Biol Chem. 2019; 294(48):18504-18515. PMC: 6885645. DOI: 10.1074/jbc.RA119.009282. View

17.

Manikkam M, Haque M, Guerrero-Bosagna C, Nilsson E, Skinner M . Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline. PLoS One. 2014; 9(7):e102091. PMC: 4109920. DOI: 10.1371/journal.pone.0102091. View

18.

Wang D, Yan S, Yan J, Teng M, Meng Z, Li R . Effects of triphenyl phosphate exposure during fetal development on obesity and metabolic dysfunctions in adult mice: Impaired lipid metabolism and intestinal dysbiosis. Environ Pollut. 2019; 246:630-638. DOI: 10.1016/j.envpol.2018.12.053. View

19.

Skinner M, Ben Maamar M, Sadler-Riggleman I, Beck D, Nilsson E, McBirney M . Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease. Epigenetics Chromatin. 2018; 11(1):8. PMC: 5827984. DOI: 10.1186/s13072-018-0178-0. View

20.

Shoucri B, Hung V, Chamorro-Garcia R, Shioda T, Blumberg B . Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte. Endocrinology. 2018; 159(8):2863-2883. PMC: 6669823. DOI: 10.1210/en.2018-00056. View