Engineering Vertically Interrogated Interferometric Sensors for Optical Label-free Biosensing

Overview

Journal Anal Bioanal Chem

Specialty Chemistry

Date 2020 Feb 15

PMID 32055908

Citations 9

Authors

Rafael Casquel

Miguel Holgado

Maria F Laguna

Ana L Hernandez

Beatriz Santamaria

Alvaro Lavin

Luca Tramarin

Pedro Herreros

Affiliations

Soon will be listed here.

Abstract

In this work, we review the technology of vertically interrogated optical biosensors from the point of view of engineering. Vertical sensors present several advantages in the fabrication processes and in the light coupling systems, compared with other interferometric sensors. Four different interrelated aspects of the design are identified and described: sensing cell design, optical techniques used in the interrogation, fabrication processes, fluidics, and biofunctionalization of the sensing surface. The designer of a vertical sensor should decide carefully which solution to adopt on each aspect prior to finally integrating all the components in a single platform. Complexity, cost, and reliability of this platform will be determined by the decisions taken on each of the design process. We focus on the research and experience acquired by our group during last years in the field of optical biosensors.

Citing Articles

Phosphorylated Tau at T181 accumulates in the serum of hibernating Syrian hamsters and rapidly disappears after arousal.

Leon-Espinosa G, Murillo A, Turegano-Lopez M, DeFelipe J, Holgado M Sci Rep. 2024; 14(1):20562.

PMID: 39232030 PMC: 11375040. DOI: 10.1038/s41598-024-71481-5.

Comparative analysis of electrophoresis and interferometric optical detection method for molecular weight determination of proteins.

Santamaria B, L Hernandez A, Laguna M, Holgado M Heliyon. 2024; 10(16):e35932.

PMID: 39229532 PMC: 11369481. DOI: 10.1016/j.heliyon.2024.e35932.

A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies.

Pioz M, Espinosa R, Laguna M, Santamaria B, Murillo A, Hueros A Biosensors (Basel). 2022; 12(12).

PMID: 36551058 PMC: 9776401. DOI: 10.3390/bios12121091.

Efficient Chemical Surface Modification Protocol on SiO Transducers Applied to MMP9 Biosensing.

Hernandez A, Pujari S, Laguna M, Santamaria B, Zuilhof H, Holgado M Sensors (Basel). 2021; 21(23).

PMID: 34884157 PMC: 8662398. DOI: 10.3390/s21238156.

Hydrogel-based holographic sensors and biosensors: past, present, and future.

Lucio M, Cubells-Gomez A, Maquieira A, Banuls M Anal Bioanal Chem. 2021; 414(2):993-1014.

PMID: 34757475 DOI: 10.1007/s00216-021-03746-1.

References

Visser D, Choudhury B, Krasovska I, Anand S . Refractive index sensing in the visible/NIR spectrum using silicon nanopillar arrays. Opt Express. 2017; 25(11):12171-12181. DOI: 10.1364/OE.25.012171. View

Calvo M, Gonzalez-Garcia L, Parra-Barranco J, Barranco A, Jimenez-Solano A, Gonzalez-Elipe A . Flexible Distributed Bragg Reflectors from Nanocolumnar Templates. Adv Opt Mater. 2015; 3(2):171-175. PMC: 4558613. DOI: 10.1002/adom.201400338. View

Homola J . Surface plasmon resonance sensors for detection of chemical and biological species. Chem Rev. 2008; 108(2):462-93. DOI: 10.1021/cr068107d. View

Hernandez A, Casquel R, Holgado M, Cornago I, Sanza F, Santamaria B . Arrays of resonant nanopillars for biochemical sensing. Opt Lett. 2015; 40(10):2370-2. DOI: 10.1364/OL.40.002370. View

Fan X, White I, Shopova S, Zhu H, Suter J, Sun Y . Sensitive optical biosensors for unlabeled targets: a review. Anal Chim Acta. 2008; 620(1-2):8-26. PMC: 10069299. DOI: 10.1016/j.aca.2008.05.022. View

Surdo S, Barillaro G . On the performance of label-free biosensors based on vertical one-dimensional photonic crystal resonant cavities. Opt Express. 2015; 23(7):9192-201. DOI: 10.1364/OE.23.009192. View

Skivesen N, Tetu A, Kristensen M, Kjems J, Frandsen L, Borel P . Photonic-crystal waveguide biosensor. Opt Express. 2009; 15(6):3169-76. DOI: 10.1364/oe.15.003169. View

Lavin A, Vicente J, Holgado M, Laguna M, Casquel R, Santamaria B . On the Determination of Uncertainty and Limit of Detection in Label-Free Biosensors. Sensors (Basel). 2018; 18(7). PMC: 6068557. DOI: 10.3390/s18072038. View

Cross G, Reeves A, Brand S, Popplewell J, Peel L, Swann M . A new quantitative optical biosensor for protein characterisation. Biosens Bioelectron. 2003; 19(4):383-90. DOI: 10.1016/s0956-5663(03)00203-3. View

10.

Kugel V, Ji H . Nanopillars for sensing. J Nanosci Nanotechnol. 2015; 14(9):6469-77. DOI: 10.1166/jnn.2014.9346. View

11.

Ortega F, Banuls M, Sanza F, Casquel R, Laguna M, Holgado M . Biomolecular Interaction Analysis of Gestrinone-anti-Gestrinone Using Arrays of High Aspect Ratio SU-8 Nanopillars. Biosensors (Basel). 2015; 2(3):291-304. PMC: 4263551. DOI: 10.3390/bios2030291. View

12.

Casquel R, Soler J, Holgado M, Lopez A, Lavin A, De Vicente J . Sub-micrometric reflectometry for localized label-free biosensing. Opt Express. 2015; 23(10):12544-54. DOI: 10.1364/OE.23.012544. View

13.

Morton K, Nieberg G, Bai S, Chou S . Wafer-scale patterning of sub-40 nm diameter and high aspect ratio (>50:1) silicon pillar arrays by nanoimprint and etching. Nanotechnology. 2011; 19(34):345301. DOI: 10.1088/0957-4484/19/34/345301. View

14.

Aswal D, Lenfant S, Guerin D, Yakhmi J, Vuillaume D . Self assembled monolayers on silicon for molecular electronics. Anal Chim Acta. 2007; 568(1-2):84-108. DOI: 10.1016/j.aca.2005.10.027. View

15.

Seo K, Wober M, Steinvurzel P, Schonbrun E, Dan Y, Ellenbogen T . Multicolored vertical silicon nanowires. Nano Lett. 2011; 11(4):1851-6. DOI: 10.1021/nl200201b. View

16.

White I, Fan X . On the performance quantification of resonant refractive index sensors. Opt Express. 2008; 16(2):1020-8. PMC: 3071988. DOI: 10.1364/oe.16.001020. View

17.

Fernandez Gavela A, Grajales Garcia D, C Ramirez J, Lechuga L . Last Advances in Silicon-Based Optical Biosensors. Sensors (Basel). 2016; 16(3):285. PMC: 4813860. DOI: 10.3390/s16030285. View

18.

Sanza F, Holgado M, Ortega F, Casquel R, Lopez-Romero D, Banuls M . Bio-Photonic Sensing Cells over transparent substrates for anti-gestrinone antibodies biosensing. Biosens Bioelectron. 2011; 26(12):4842-7. DOI: 10.1016/j.bios.2011.06.010. View

19.

Barrios C, Banuls M, Gonzalez-Pedro V, Gylfason K, Sanchez B, Griol A . Label-free optical biosensing with slot-waveguides. Opt Lett. 2008; 33(7):708-10. DOI: 10.1364/ol.33.000708. View

20.

Canalejas-Tejero V, Herranz S, Bellingham A, Moreno-Bondi M, Barrios C . Passivated aluminum nanohole arrays for label-free biosensing applications. ACS Appl Mater Interfaces. 2013; 6(2):1005-10. DOI: 10.1021/am404509f. View