Low Skeletal Muscle Mass is Associated with Arterial Stiffness in Community-dwelling Chinese Aged 45 years and Older

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2020 Feb 15

PMID 32054503

Citations 6

Authors

Mingzhe Yang

Xuguang Zhang

Zhenkai Ding

Feijie Wang

Yufang Wang

Changya Jiao

Jie-Hua Chen

Affiliations

Soon will be listed here.

Abstract

Background: Evidence suggests that body composition has impact on arterial stiffness. However, evidence in Chinese are limited, and results remain controversial. The aim of our study is to investigate whether skeletal muscle mass is associated with arterial stiffness in Chinese community-dwelling men and women aged 45 years and older.

Methods: In this cross-sectional study, 20,477 participants (age range: 45-80 years, 68.8% women) were included in the analysis. Brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness was measured using a waveform device. Total muscle mass and muscle mass of arm, leg and trunk were measured by bioelectrical impedance analysis. Height and weight were measured and appendicular skeletal muscle mass index (ASMI) was calculated as appendicular skeletal muscle mass (sum of arm and leg muscle mass) divided by height square.

Results: After adjustment for age, body fat percentage, systolic blood pressure and diastolic blood pressure, ASMI was negatively associated with baPWV [β (SE) for men: - 0.208 (0.016), p < 0.0001; for women: - 0.245 (0.012), p < 0.0001]. High ASMI was a protective factor for the presence of arterial stiffness (defined as baPWV) [OR (95%CI) for men: 0.730 (0.682, 0.782), p < 0.0001; women: 0.634 (0.593, 0.677), p < 0.0001]. Similar associations were found between quantity of muscle mass (total and appendicular muscle mass, muscle mass of arm, leg and trunk) and arterial stiffness in men and women after further adjustment for height (all p < 0.0001).

Conclusion: Low skeletal muscle mass is associated with increased risk of arterial stiffness in Chinese community-dwelling adults aged 45 years and older.

Citing Articles

Association between Skeletal Muscle Characteristics and Arterial Stiffness: Chronic Limb-Threatening Ischemia the Key Element.

Ferreira J, Roque S, Vila I, Mansilha A, Cunha P Int J Angiol. 2025; 34(1):72-74.

PMID: 39944145 PMC: 11813607. DOI: 10.1055/s-0044-1786396.

Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects.

Jung K, Kim Y, Shin H, Park C Sci Rep. 2025; 15(1):1952.

PMID: 39809920 PMC: 11732984. DOI: 10.1038/s41598-025-85505-1.

Bioelectrical impedance analysis predicts prehypertension and hypertension: A hospital-based cross-sectional study.

Yogesh M, Mody M, Patel J, Shah S, Makwana N, Nagda J J Family Med Prim Care. 2024; 13(10):4336-4342.

PMID: 39629404 PMC: 11610864. DOI: 10.4103/jfmpc.jfmpc_408_24.

Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome.

Sanchez-Delgado J, Cohen D, Camacho-Lopez P, Carreno-Robayo J, Castaneda-Hernandez A, Garcia-Gonzalez D Biomedicines. 2023; 11(9).

PMID: 37760876 PMC: 10525985. DOI: 10.3390/biomedicines11092435.

Associations of cardiorespiratory fitness, body composition, and blood pressure with arterial stiffness in adolescent, young adult, and middle-aged women.

Haapala E, Lee E, Karppinen J, Skog H, Valtonen M, Kujala U Sci Rep. 2022; 12(1):21378.

PMID: 36494498 PMC: 9734157. DOI: 10.1038/s41598-022-25795-x.

References

Zhan B, Huang X, Wang J, Qin X, Zhang J, Cao J . Association Between Lipid Profiles and Arterial Stiffness in Chinese Patients With Hypertension: Insights From the CSPPT. Angiology. 2019; 70(6):515-522. DOI: 10.1177/0003319718823341. View

Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Pariggiano I . Inflammation and cardiovascular disease: from pathogenesis to therapeutic target. Curr Atheroscler Rep. 2014; 16(9):435. DOI: 10.1007/s11883-014-0435-z. View

Ikonomidis I, Lambadiari V, Pavlidis G, Koukoulis C, Kousathana F, Varoudi M . Insulin resistance and acute glucose changes determine arterial elastic properties and coronary flow reserve in dysglycaemic and first-degree relatives of diabetic patients. Atherosclerosis. 2015; 241(2):455-62. DOI: 10.1016/j.atherosclerosis.2015.06.006. View

Luo K, Feng X, Xu B, Long H . Association between arterial stiffness and risk of coronary artery disease. Pak J Med Sci. 2015; 30(6):1314-8. PMC: 4320722. DOI: 10.12669/pjms.306.5584. View

Wang J, Zhou Z, Hu D . Prevalence of arterial stiffness in North China, and associations with risk factors of cardiovascular disease: a community-based study. BMC Cardiovasc Disord. 2012; 12:119. PMC: 3523088. DOI: 10.1186/1471-2261-12-119. View

Gerhard-Herman M, Gornik H, Barrett C, Barshes N, Corriere M, Drachman D . 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2016; 135(12):e686-e725. PMC: 5479414. DOI: 10.1161/CIR.0000000000000470. View

Dmitruk A, Czeczelewski J, Czeczelewska E, Golach J, Parnicka U . Body composition and fatty tissue distribution in women with various menstrual status. Rocz Panstw Zakl Hig. 2018; 69(1):95-101. View

Vlachopoulos C, Aznaouridis K, Stefanadis C . Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 55(13):1318-27. DOI: 10.1016/j.jacc.2009.10.061. View

Abbatecola A, Chiodini P, Gallo C, Lakatta E, Sutton-Tyrrell K, Tylavsky F . Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age (Dordr). 2011; 34(2):469-78. PMC: 3312626. DOI: 10.1007/s11357-011-9238-0. View

10.

Kim M, Kim M, Yoo H, Lee S, Lee S, Lee J . Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress. J Atheroscler Thromb. 2017; 25(2):178-185. PMC: 5827087. DOI: 10.5551/jat.39388. View

11.

Tomiyama H, Matsumoto C, Shiina K, Yamashina A . Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors. J Atheroscler Thromb. 2015; 23(2):128-46. DOI: 10.5551/jat.32979. View

12.

Ferreira I, Snijder M, Twisk J, van Mechelen W, Kemper H, Seidell J . Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study. J Clin Endocrinol Metab. 2004; 89(6):2632-9. DOI: 10.1210/jc.2003-031619. View

13.

Aleman-Mateo H, Lopez Teros M, Ramirez F, Astiazaran-Garcia H . Association between insulin resistance and low relative appendicular skeletal muscle mass: evidence from a cohort study in community-dwelling older men and women participants. J Gerontol A Biol Sci Med Sci. 2013; 69(7):871-7. DOI: 10.1093/gerona/glt193. View

14.

Sterkowicz S, Jaworski J, Lech G, Palka T, Sterkowicz-Przybycien K, Bujas P . Effect of Acute Effort on Isometric Strength and Body Balance: Trained vs. Untrained Paradigm. PLoS One. 2016; 11(5):e0155985. PMC: 4878781. DOI: 10.1371/journal.pone.0155985. View

15.

Sanada K, Miyachi M, Tanimoto M, Yamamoto K, Murakami H, Okumura S . A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol. 2010; 110(1):57-65. DOI: 10.1007/s00421-010-1473-z. View

16.

Bredella M . Sex Differences in Body Composition. Adv Exp Med Biol. 2017; 1043:9-27. DOI: 10.1007/978-3-319-70178-3_2. View

17.

Zhang L, Guo Q, Feng B, Wang C, Han P, Hu J . A Cross-Sectional Study of the Association between Arterial Stiffness and Sarcopenia in Chinese Community-Dwelling Elderly Using the Asian Working Group for Sarcopenia Criteria. J Nutr Health Aging. 2019; 23(2):195-201. DOI: 10.1007/s12603-018-1147-9. View

18.

Ochi M, Kohara K, Tabara Y, Kido T, Uetani E, Ochi N . Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis. 2010; 212(1):327-32. DOI: 10.1016/j.atherosclerosis.2010.05.026. View

19.

Wu M, Wei Y, Yu C, Du H, Lyu J, Guo Y . [Levels of skeletal muscle mass and handgrip strength in adults from 10 regions of China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2019; 40(4):376-381. DOI: 10.3760/cma.j.issn.0254-6450.2019.04.002. View

20.

Takashima N, Turin T, Matsui K, Rumana N, Nakamura Y, Kadota A . The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study. J Hum Hypertens. 2013; 28(5):323-7. DOI: 10.1038/jhh.2013.103. View