Age-Specific Determinants of Pulse Wave Velocity Among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress

Overview

Journal J Atheroscler Thromb

Date 2017 Jul 26

PMID 28740031

Citations 22

Authors

Minkyung Kim

Minjoo Kim

Hye Jin Yoo

Seung Yeon Lee

Sang-Hyun Lee

Jong Ho Lee

Affiliations

Soon will be listed here.

Abstract

Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress.

Methods: A total of 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 y (n=1,413), 45-54 y (n=1,384), and 55-79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured.

Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F (8-epi-PGF), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19-34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35-44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45-54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55-79 y group.

Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

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References

Tomiyama H, Matsumoto C, Shiina K, Yamashina A . Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors. J Atheroscler Thromb. 2015; 23(2):128-46. DOI: 10.5551/jat.32979. View

Yeo H, Kim O, Lim H, Kim J, Lee J . Association of serum lycopene and brachial-ankle pulse wave velocity with metabolic syndrome. Metabolism. 2010; 60(4):537-43. DOI: 10.1016/j.metabol.2010.05.003. View

ORourke M, Hashimoto J . Mechanical factors in arterial aging: a clinical perspective. J Am Coll Cardiol. 2007; 50(1):1-13. DOI: 10.1016/j.jacc.2006.12.050. View

Cabral de Faria A, Fontana V, Modolo R, Ruggeri Barbaro N, Sabbatini A, Pansani I . Plasma 8-isoprostane levels are associated with endothelial dysfunction in resistant hypertension. Clin Chim Acta. 2014; 433:179-83. DOI: 10.1016/j.cca.2014.03.009. View

Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S . Urinary 8-iso-prostaglandin F2α as a marker of metabolic risks in the general Japanese population: The ROAD study. Obesity (Silver Spring). 2015; 23(7):1517-24. DOI: 10.1002/oby.21130. View

Aronson D . Hyperglycemia and the pathobiology of diabetic complications. Adv Cardiol. 2008; 45:1-16. DOI: 10.1159/000115118. View

Aguilar D, Fisher M, OConnor C, Dunne M, Muhlestein J, Yao L . Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease. Am Heart J. 2006; 152(2):298-304. DOI: 10.1016/j.ahj.2005.11.011. View

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View

Chen L, Zhu W, Mai L, Fang L, Ying K . The association of metabolic syndrome and its components with brachial-ankle pulse wave velocity in south China. Atherosclerosis. 2015; 240(2):345-50. DOI: 10.1016/j.atherosclerosis.2015.03.031. View

10.

Jimi S, Saku K, Uesugi N, Sakata N, Takebayashi S . Oxidized low density lipoprotein stimulates collagen production in cultured arterial smooth muscle cells. Atherosclerosis. 1995; 116(1):15-26. DOI: 10.1016/0021-9150(95)05515-x. View

11.

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

12.

. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285(19):2486-97. DOI: 10.1001/jama.285.19.2486. View

13.

Stocker R, Keaney Jr J . Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004; 84(4):1381-478. DOI: 10.1152/physrev.00047.2003. View

14.

Joo H, Cho S, Cho J, Lee S, Park J, Hwang S . Brachial-Ankle Pulse Wave Velocity is Associated with Composite Carotid and Coronary Atherosclerosis in a Middle-Aged Asymptomatic Population. J Atheroscler Thromb. 2016; 23(9):1033-46. PMC: 5090810. DOI: 10.5551/jat.33084. View

15.

Holvoet P, Stassen J, Van Cleemput J, Collen D, Vanhaecke J . Oxidized low density lipoproteins in patients with transplant-associated coronary artery disease. Arterioscler Thromb Vasc Biol. 1998; 18(1):100-7. DOI: 10.1161/01.atv.18.1.100. View

16.

Vlachopoulos C, Aznaouridis K, Stefanadis C . Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 55(13):1318-27. DOI: 10.1016/j.jacc.2009.10.061. View

17.

Ahn H, Kim M, Chae J, Ahn Y, Sim J, Choi I . Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia. Atherosclerosis. 2015; 241(2):649-56. DOI: 10.1016/j.atherosclerosis.2015.06.030. View

18.

Brinkley T, Nicklas B, Kanaya A, Satterfield S, Lakatta E, Simonsick E . Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study. Hypertension. 2009; 53(5):846-52. PMC: 2692957. DOI: 10.1161/HYPERTENSIONAHA.108.127043. View

19.

. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004; 363(9403):157-63. DOI: 10.1016/S0140-6736(03)15268-3. View

20.

Matthys K, Van Hove C, Kockx M, Andries L, Van Osselaer N, Herman A . Local application of LDL promotes intimal thickening in the collared carotid artery of the rabbit. Arterioscler Thromb Vasc Biol. 1997; 17(11):2423-9. DOI: 10.1161/01.atv.17.11.2423. View