Brain Structural and Functional Imaging Findings in Medication-Overuse Headache

Overview

Journal Front Neurol

Specialty Neurology

Date 2020 Feb 13

PMID 32047470

Citations 4

Authors

Catherine D Chong

Affiliations

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Abstract

This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was overused. Results of this narrative review indicate exacerbated brain structural and functional changes in regions of the pain-matrix and in regions of the mesocortical-limbic circuit in patients with MOH compared to patients with migraine or compared to healthy controls. Modification of brain morphology as well as an association between brain recovery and medication withdrawal suggest that the MOH disease process involves state (brain modification) and trait-like (brain adaptation and recovery) neuromechanisms.

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References

Rossi P, Faroni J, Nappi G . Short-term effectiveness of simple advice as a withdrawal strategy in simple and complicated medication overuse headache. Eur J Neurol. 2010; 18(3):396-401. DOI: 10.1111/j.1468-1331.2010.03157.x. View

Androulakis X, Krebs K, Jenkins C, Maleki N, Finkel A, Rorden C . Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine. J Neurol Disord. 2018; 6(5). PMC: 6298435. DOI: 10.4172/2329-6895.1000393. View

. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1545-1602. PMC: 5055577. DOI: 10.1016/S0140-6736(16)31678-6. View

Dumkrieger G, Chong C, Ross K, Berisha V, Schwedt T . Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: A resting-state magnetic resonance imaging study. Cephalalgia. 2019; 39(11):1366-1381. DOI: 10.1177/0333102419847728. View

Bogdanov V, Bogdanova O, Vigano A, Noirhomme Q, Laureys S, Dallel R . Increased cerebral responses to salient transitions between alternating stimuli in chronic migraine with medication overuse headache and during migraine attacks. Cephalalgia. 2019; 39(8):988-999. DOI: 10.1177/0333102418825359. View

Torta D, Costa T, Luda E, Barisone M, Palmisano P, Duca S . Nucleus accumbens functional connectivity discriminates medication-overuse headache. Neuroimage Clin. 2016; 11:686-693. PMC: 4900511. DOI: 10.1016/j.nicl.2016.05.007. View

Ferraro S, Grazzi L, Muffatti R, Nava S, Ghielmetti F, Bertolino N . In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas. Headache. 2012; 52(10):1520-34. DOI: 10.1111/j.1526-4610.2012.02276.x. View

Lai T, Chou K, Fuh J, Lee P, Kung Y, Lin C . Gray matter changes related to medication overuse in patients with chronic migraine. Cephalalgia. 2016; 36(14):1324-1333. DOI: 10.1177/0333102416630593. View

Mehnert J, Hebestreit J, May A . Cortical and Subcortical Alterations in Medication Overuse Headache. Front Neurol. 2018; 9:499. PMC: 6026656. DOI: 10.3389/fneur.2018.00499. View

10.

De Felice M, Ossipov M, Porreca F . Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache. Curr Opin Neurol. 2011; 24(3):193-6. PMC: 5690482. DOI: 10.1097/WCO.0b013e328346af25. View

11.

Zeeberg P, Olesen J, Jensen R . Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness. Cephalalgia. 2006; 26(10):1192-8. DOI: 10.1111/j.1468-2982.2006.01190.x. View

12.

London E, Ernst M, Grant S, Bonson K, Weinstein A . Orbitofrontal cortex and human drug abuse: functional imaging. Cereb Cortex. 2000; 10(3):334-42. DOI: 10.1093/cercor/10.3.334. View

13.

Krebs K, Rorden C, Androulakis X . Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study. Headache. 2018; 58(5):732-743. DOI: 10.1111/head.13318. View

14.

Schmidt-Wilcke T, Leinisch E, Straube A, Kampfe N, Draganski B, Diener H . Gray matter decrease in patients with chronic tension type headache. Neurology. 2005; 65(9):1483-6. DOI: 10.1212/01.wnl.0000183067.94400.80. View

15.

Fumal A, Laureys S, Di Clemente L, Boly M, Bohotin V, Vandenheede M . Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain. 2005; 129(Pt 2):543-50. DOI: 10.1093/brain/awh691. View

16.

Grazzi L, Chiapparini L, Ferraro S, Usai S, Andrasik F, Mandelli M . Chronic migraine with medication overuse pre-post withdrawal of symptomatic medication: clinical results and FMRI correlations. Headache. 2010; 50(6):998-1004. DOI: 10.1111/j.1526-4610.2010.01695.x. View

17.

. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1):1-211. DOI: 10.1177/0333102417738202. View

18.

Chen Z, Chen X, Liu M, Dong Z, Ma L, Yu S . Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI. J Headache Pain. 2017; 18(1):25. PMC: 5318354. DOI: 10.1186/s10194-017-0735-0. View

19.

Evers S, Marziniak M . Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol. 2010; 9(4):391-401. DOI: 10.1016/S1474-4422(10)70008-9. View

20.

Riederer F, Schaer M, Gantenbein A, Luechinger R, Michels L, Kaya M . Cortical Alterations in Medication-Overuse Headache. Headache. 2016; 57(2):255-265. DOI: 10.1111/head.12993. View