Nucleus Accumbens Functional Connectivity Discriminates Medication-overuse Headache

Overview

Journal Neuroimage Clin

Publisher Elsevier

Specialties Neurology
Radiology

Date 2016 Jun 23

PMID 27330969

Citations 17

Authors

D M Torta

T Costa

E Luda

M G Barisone

P Palmisano

S Duca

G Geminiani

F Cauda

Affiliations

Soon will be listed here.

Abstract

Medication-overuse headache (MOH) is a secondary form of headache related to the overuse of triptans, analgesics and other acute headache medications. It is believed that MOH and substance addiction share some similar pathophysiological mechanisms. In this study we examined the whole brain resting state functional connectivity of the dorsal and ventral striatum in 30 patients (15 MOH and 15 non-MOH patients) to investigate if classification algorithms can successfully discriminate between MOH and non-MOH patients on the basis of the spatial pattern of resting state functional connectivity of the dorsal and ventral striatal region of interest. Our results indicated that both nucleus accumbens and dorsal rostral putamen functional connectivity could discriminate between MOH and non-MOH patients, thereby providing possible support to two interpretations. First, that MOH patients show altered reward functionality in line with drug abusers (alterations in functional connectivity of the nucleus accumbens). Second, that MOH patients show inability to break habitual behavior (alterations in functional connectivity of the dorsal striatum). In conclusion, our data showed that MOH patients were characterized by an altered functional connectivity of motivational circuits at rest. These differences could permit the blind discrimination between the two conditions using classification algorithms. Considered overall, our findings might contribute to the development of novel diagnostic measures.

Citing Articles

Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study.

Sun Y, Ma L, Wang S, Duan C, Wang X, Bian X J Headache Pain. 2025; 26(1):54.

PMID: 40082790 PMC: 11908087. DOI: 10.1186/s10194-025-01988-3.

Medication-overuse headache: a narrative review.

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A Descriptive Review of Medication-Overuse Headache: From Pathophysiology to the Comorbidities.

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Altered cerebral neurovascular coupling in medication-overuse headache: A study combining multi-modal resting-state fMRI with 3D PCASL.

Li X, Liu M, Fan W, Xu H, Chen Z Front Neurosci. 2023; 17:1139086.

PMID: 37008219 PMC: 10050465. DOI: 10.3389/fnins.2023.1139086.

Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging.

Li C, Dai W, Miao S, Xie W, Yu S Front Neurol. 2023; 14:1118929.

PMID: 36937526 PMC: 10017752. DOI: 10.3389/fneur.2023.1118929.

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