Angiocrine Endothelium: from Physiology to Cancer

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2020 Feb 5

PMID 32014047

Citations 37

Authors

Jennifer Pasquier

Pegah Ghiabi

Lotfi Chouchane

Kais Razzouk

Shahin Rafii

Arash Rafii

Affiliations

Soon will be listed here.

Abstract

The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.

Citing Articles

Blood flow-induced angiocrine signals promote organ growth and regeneration.

Follert P, Grosse-Segerath L, Lammert E Bioessays. 2024; 47(2):e2400207.

PMID: 39529434 PMC: 11755702. DOI: 10.1002/bies.202400207.

Targeting the tumour vasculature: from vessel destruction to promotion.

Guelfi S, Hodivala-Dilke K, Bergers G Nat Rev Cancer. 2024; 24(10):655-675.

PMID: 39210063 DOI: 10.1038/s41568-024-00736-0.

VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane.

Li Q, Guo M, He G, Xi K, Zhou M, Shi R Oncogene. 2024; 43(24):1836-1851.

PMID: 38654108 DOI: 10.1038/s41388-024-03038-9.

Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer.

Lei X, Li Z, Huang M, Huang L, Huang Y, Lv S J Exp Clin Cancer Res. 2024; 43(1):83.

PMID: 38493151 PMC: 10944600. DOI: 10.1186/s13046-024-03003-0.

Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts.

Watanabe-Takano H, Kato K, Oguri-Nakamura E, Ishii T, Kobayashi K, Murata T Nat Commun. 2024; 15(1):1622.

PMID: 38438343 PMC: 10912381. DOI: 10.1038/s41467-024-45910-y.

References

Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y . Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell. 2010; 7(2):163-73. PMC: 2916873. DOI: 10.1016/j.stem.2010.05.019. View

Bhargava P, Robinson M . Development of second-generation VEGFR tyrosine kinase inhibitors: current status. Curr Oncol Rep. 2011; 13(2):103-11. PMC: 3047052. DOI: 10.1007/s11912-011-0154-3. View

Zeng Q, Li S, Chepeha D, Giordano T, Li J, Zhang H . Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell. 2005; 8(1):13-23. DOI: 10.1016/j.ccr.2005.06.004. View

Chen L, Ashe S, Brady W, Hellstrom I, Hellstrom K, Ledbetter J . Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell. 1992; 71(7):1093-102. DOI: 10.1016/s0092-8674(05)80059-5. View

Nelson C, Khauv D, Bissell M, Radisky D . Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008; 105(1):25-33. PMC: 2838485. DOI: 10.1002/jcb.21821. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

Quintieri L, Selmy M, Indraccolo S . Metabolic effects of antiangiogenic drugs in tumors: therapeutic implications. Biochem Pharmacol. 2014; 89(2):162-70. DOI: 10.1016/j.bcp.2014.02.018. View

Ding B, Nolan D, Guo P, Babazadeh A, Cao Z, Rosenwaks Z . Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011; 147(3):539-53. PMC: 3228268. DOI: 10.1016/j.cell.2011.10.003. View

Crouch E, Liu C, Silva-Vargas V, Doetsch F . Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015; 35(11):4528-39. PMC: 4363382. DOI: 10.1523/JNEUROSCI.1188-14.2015. View

10.

Quintana E, Shackleton M, Sabel M, Fullen D, Johnson T, Morrison S . Efficient tumour formation by single human melanoma cells. Nature. 2008; 456(7222):593-8. PMC: 2597380. DOI: 10.1038/nature07567. View

11.

Zhou L, Li J, Zhao Y, Guo J, Cui Q, Zhou W . Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer. Hepatobiliary Pancreat Dis Int. 2014; 13(5):523-8. DOI: 10.1016/s1499-3872(14)60272-1. View

12.

Tufro A, Norwood V, Carey R, Gomez R . Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol. 1999; 10(10):2125-34. DOI: 10.1681/ASN.V10102125. View

13.

Casanovas O . The adaptive stroma joining the antiangiogenic resistance front. J Clin Invest. 2011; 121(4):1244-7. PMC: 3069791. DOI: 10.1172/JCI46430. View

14.

McKinney N, Yuan L, Zhang H, Liu J, Cho Y, Rushing E . EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma. J Neurooncol. 2014; 121(1):109-18. PMC: 4293301. DOI: 10.1007/s11060-014-1618-8. View

15.

Motzer R, Escudier B, Tomczak P, Hutson T, Michaelson M, Negrier S . Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol. 2013; 14(6):552-62. DOI: 10.1016/S1470-2045(13)70093-7. View

16.

Silva-Vargas V, Doetsch F . A new twist for neurotrophins: endothelial-derived NT-3 mediates adult neural stem cell quiescence. Neuron. 2014; 83(3):507-9. DOI: 10.1016/j.neuron.2014.07.029. View

17.

Korc M . Pathways for aberrant angiogenesis in pancreatic cancer. Mol Cancer. 2003; 2:8. PMC: 149422. DOI: 10.1186/1476-4598-2-8. View

18.

Raymond E, Dahan L, Raoul J, Bang Y, Borbath I, Lombard-Bohas C . Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011; 364(6):501-13. DOI: 10.1056/NEJMoa1003825. View

19.

Hoarau-Vechot J, Touboul C, Halabi N, Blot-Dupin M, Lis R, Abi Khalil C . Akt-activated endothelium promotes ovarian cancer proliferation through notch activation. J Transl Med. 2019; 17(1):194. PMC: 6558713. DOI: 10.1186/s12967-019-1942-z. View

20.

Matsumoto K, Yoshitomi H, Rossant J, Zaret K . Liver organogenesis promoted by endothelial cells prior to vascular function. Science. 2001; 294(5542):559-63. DOI: 10.1126/science.1063889. View