Deep Eutectic Solvents As Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds En Route to Donepezil-Like Compounds

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Feb 5

PMID 32013037

Citations 12

Authors

Luca Piemontese

Roberta Sergio

Federica Rinaldo

Leonardo Brunetti

Filippo M Perna

M Amelia Santos

Vito Capriati

Affiliations

Soon will be listed here.

Abstract

An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer's disease (AD) treatment. Building upon these findings, we have now designed and completed the whole synthesis of PZ1 in the so-called deep eutectic solvents (DESs), which have emerged as an unconventional class of bio-renewable reaction media in green synthesis. Under optimized reaction conditions, the preparation of a series of 2-hydroxyphenylbenzimidazole-based nuclei has also been perfected in DESs, and comparison with other routes which employ toxic and volatile organic solvents (VOCs) provided. The functionalization of the aromatic ring can have implications on some important biological properties of the described derivatives and will be the subject of future studies of structure-activity relationships (SARs).

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