EMT Signaling: Potential Contribution of CRISPR/Cas Gene Editing

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2020 Feb 3

PMID 32008085

Citations 14

Authors

Reza Mohammadinejad

Alessio Biagioni

Ganesan Arunkumar

Rebecca Shapiro

Kun-Che Chang

Mohammed Sedeeq

Aftab Taiyab

Mohammad Hashemabadi

Abbas Pardakhty

Ali Mandegary

Jean-Paul Thiery

Amir Reza Aref

Iman Azimi

Affiliations

Soon will be listed here.

Abstract

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

Citing Articles

Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial-Mesenchymal Transition.

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Editorial: CRISPR advancement in cancer research and future perspectives.

Biagioni A, Mohammadinejad R Front Oncol. 2023; 13:1173527.

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Pan-sarcoma characterization of lncRNAs in the crosstalk of EMT and tumour immunity identifies distinct clinical outcomes and potential implications for immunotherapy.

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