Protective Effect of D-pinitol on the Experimental Spinal Cord Injury in Rats

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2020 Jan 31

PMID 31997266

Citations 4

Authors

Yan An

Jianing Li

Yajun Liu

Mingxing Fan

Wei Tian

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) is the major cause of the spinal damage affecting motor and sensory function. Thus, the present study was conducted to investigate the effect of D-pinitol (PN) on spinal cord injury in rats. The PN showed to recover motor function near to normal via modulating oxidative stress, inflammatory response and cellular apoptosis in SCI rats. PN also causes modulation of Bcl2 family proteins and reduces the level of NF-ĸB and LOX-1 in dose dependent manner. The PN causes reduction of NLRP3, TNF-α and iNOS, with increase in caspase-1 together with modulation of MAPK mediators. It has been suggested that, D-pinitol exert protective action against SCI via inhibition of apoptosis, inflammation and oxidative stress, via modulating Bcl-2 genes and MAPK pathway.

Citing Articles

The role of foam cells in spinal cord injury: challenges and opportunities for intervention.

Wang X, Li Z, Du H, Liu W, Zhang C, Xu X Front Immunol. 2024; 15:1368203.

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Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice.

Li X, Gao Y, Li B, Zhao W, Cai Q, Yin W Front Mol Neurosci. 2023; 16:1251513.

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D-Pinitol-Active Natural Product from Carob with Notable Insulin Regulation.

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d-Pinitol protects against endoplasmic reticulum stress and apoptosis in hepatic ischemia-reperfusion injury via modulation of AFT4-CHOP/GRP78 and caspase-3 signaling pathways.

Yan L, Luo H, Li X, Li Y Int J Immunopathol Pharmacol. 2021; 35:20587384211032098.

PMID: 34275383 PMC: 8287360. DOI: 10.1177/20587384211032098.

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