The Role of Lozenge in Hematopoiesis

Overview

Journal Mol Cells

Publisher Elsevier

Specialties Cell Biology
Molecular Biology

Date 2020 Jan 30

PMID 31992020

Citations 8

Authors

Ferdinand Koranteng

Nuri Cha

Mingyu Shin

Jiwon Shim

Affiliations

Soon will be listed here.

Abstract

hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in will enlighten our perspectives on Runx-mediated development and pathologies.

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