Dpp Dependent Hematopoietic Stem Cells Give Rise to Hh Dependent Blood Progenitors in Larval Lymph Gland of

Overview

Journal Elife

Specialty Biology

Date 2016 Nov 1

PMID 27782877

Citations 29

Authors

Nidhi Sharma Dey

Parvathy Ramesh

Mayank Chugh

Sudip Mandal

Lolitika Mandal

Affiliations

Soon will be listed here.

Abstract

hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in , the larval lymph gland with its Hedgehog dependent progenitors served as an invertebrate model of progenitor biology. Employing lineage-tracing analyses, we have now identified expressing HSCs in the first instar larval lymph gland. Our studies clearly establish the hierarchical relationship between expressing HSCs and the previously described expressing progenitors. These HSCs require Decapentapelagic (Dpp) signal from the hematopoietic niche for their maintenance in an identical manner to vertebrate aorta-gonadal-mesonephros (AGM) HSCs. Thus, this study not only extends the conservation across these divergent taxa, but also provides a new model that can be exploited to gain better insight into the AGM related Hematopoietic stem cells (HSCs).

Citing Articles

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References

Mikkola H, Orkin S . The journey of developing hematopoietic stem cells. Development. 2006; 133(19):3733-44. DOI: 10.1242/dev.02568. View

Medvinsky A, Rybtsov S, Taoudi S . Embryonic origin of the adult hematopoietic system: advances and questions. Development. 2011; 138(6):1017-31. DOI: 10.1242/dev.040998. View

Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H . Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell. 2008; 132(3):487-98. DOI: 10.1016/j.cell.2007.12.033. View

Kurucz E, Vaczi B, Markus R, Laurinyecz B, Vilmos P, Zsamboki J . Definition of Drosophila hemocyte subsets by cell-type specific antigens. Acta Biol Hung. 2008; 58 Suppl:95-111. DOI: 10.1556/ABiol.58.2007.Suppl.8. View

Markus R, Laurinyecz B, Kurucz E, Honti V, Bajusz I, Sipos B . Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2009; 106(12):4805-9. PMC: 2660760. DOI: 10.1073/pnas.0801766106. View

Rehorn K, Thelen H, MICHELSON A, Reuter R . A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila. Development. 1996; 122(12):4023-31. DOI: 10.1242/dev.122.12.4023. View

Robin C, Durand C . The roles of BMP and IL-3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo. Int J Dev Biol. 2010; 54(6-7):1189-200. DOI: 10.1387/ijdb.093040cr. View

Kim P, Albacker C, Lu Y, Jang I, Lim Y, Heffner G . Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2012; 110(2):E141-50. PMC: 3545793. DOI: 10.1073/pnas.1214361110. View

Nakano H, Liu X, Arshi A, Nakashima Y, Van Handel B, Sasidharan R . Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun. 2013; 4:1564. PMC: 3612528. DOI: 10.1038/ncomms2569. View

10.

Yuan H, Yamashita Y . Germline stem cells: stems of the next generation. Curr Opin Cell Biol. 2010; 22(6):730-6. PMC: 2993778. DOI: 10.1016/j.ceb.2010.08.013. View

11.

Duvic B, Hoffmann J, Meister M, Royet J . Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Curr Biol. 2002; 12(22):1923-7. DOI: 10.1016/s0960-9822(02)01297-6. View

12.

Wang H, Singh S, Zheng Z, Oh S, Chen X, Edwards K . Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev Cell. 2006; 10(1):117-26. DOI: 10.1016/j.devcel.2005.11.004. View

13.

Krzemien J, Dubois L, Makki R, Meister M, Vincent A, Crozatier M . Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature. 2007; 446(7133):325-8. DOI: 10.1038/nature05650. View

14.

Honti V, Csordas G, Markus R, Kurucz E, Jankovics F, Ando I . Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster. Mol Immunol. 2010; 47(11-12):1997-2004. DOI: 10.1016/j.molimm.2010.04.017. View

15.

Kiel M, Morrison S . Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008; 8(4):290-301. DOI: 10.1038/nri2279. View

16.

Stine R, Matunis E . JAK-STAT signaling in stem cells. Adv Exp Med Biol. 2013; 786:247-67. DOI: 10.1007/978-94-007-6621-1_14. View

17.

Lin H . The stem-cell niche theory: lessons from flies. Nat Rev Genet. 2002; 3(12):931-40. DOI: 10.1038/nrg952. View

18.

Mandal L, Banerjee U, Hartenstein V . Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm. Nat Genet. 2004; 36(9):1019-23. DOI: 10.1038/ng1404. View

19.

Golub R, Cumano A . Embryonic hematopoiesis. Blood Cells Mol Dis. 2013; 51(4):226-31. DOI: 10.1016/j.bcmd.2013.08.004. View

20.

Mondal B, Mukherjee T, Mandal L, Evans C, Sinenko S, Martinez-Agosto J . Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011; 147(7):1589-600. PMC: 4403793. DOI: 10.1016/j.cell.2011.11.041. View