Endothelin-1 Rs9296344 Associates with the Susceptibility of Childhood Primary Nephrotic Syndrome

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2020 Jan 26

PMID 31981468

Citations 2

Authors

Ruifeng Zhang

Huandan Yang

Bingbing Zhu

Tingting Yuan

Qianqian Peng

Juan Lv

Shan Qiu

Suqin Zhou

Yan Li

Zhaowen Zhong

Affiliations

Soon will be listed here.

Abstract

Background: Recently, the rs5370 single nucleotide polymorphisms (SNPs) of Endothelin-1 (EDN1) showed association with the susceptibility of childhood primary nephrotic syndrome (CPNS). This study aims to investigate potential relationships between other EDN1 SNPs and CPNS.

Methods: Seven SNPs (rs5370, rs10478723, rs1476046, rs1800541, rs2070698, rs2071942, and rs9296344) of the EDN1 gene were genotyped in 579 CPNS patients and 586 age-matched healthy children. Then, we analyzed potential associations of the six SNPs with susceptibility of CPNS by using rs5370 as a conditional variant in a logistic regression model. SNP-SNP interaction analysis was performed to investigate the joint effects of the seven SNPs in the pathogenesis of CPNS.

Results: Independent with rs5370, only rs9296344 significantly associated (T vs C, odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.57-0.88, P = .001) with the susceptibility of CPNS. Meanwhile, no joint effect among the analyzed seven SNPs was discovered in this study.

Conclusions: This study discovered that C allele of rs9296344 on EDN1 is a novel independent risk factor for CPNS.

Citing Articles

Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long-Term Response to Atrasentan in Patients With Diabetic Kidney Disease.

Smeijer J, Koomen J, Kohan D, McMurray J, Bakris G, Correa-Rotter R Clin Pharmacol Ther. 2022; 112(5):1098-1107.

PMID: 35892316 PMC: 9804438. DOI: 10.1002/cpt.2721.

Endothelin-1 rs9296344 associates with the susceptibility of childhood primary nephrotic syndrome.

Zhang R, Yang H, Zhu B, Yuan T, Peng Q, Lv J J Clin Lab Anal. 2020; 34(4):e23134.

PMID: 31981468 PMC: 7171328. DOI: 10.1002/jcla.23134.

References

Zhang S, Zhu Q, Ding X, Lin S, Zhao J, Guan L . Prognostic value of and in resected non-small cell lung cancer: a systematic review and meta-analysis. Cancer Manag Res. 2018; 10:3393-3404. PMC: 6138965. DOI: 10.2147/CMAR.S167578. View

Downie M, Gallibois C, Parekh R, Noone D . Nephrotic syndrome in infants and children: pathophysiology and management. Paediatr Int Child Health. 2017; 37(4):248-258. DOI: 10.1080/20469047.2017.1374003. View

Kim M, Cho M, Kim J, Ahn Y, Choi H, Ha I . Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients. Kidney Res Clin Pract. 2019; 37(4):347-355. PMC: 6312784. DOI: 10.23876/j.krcp.18.0098. View

He B, Li T, Guan L, Liu F, Chen X, Zhao J . CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425. Oncotarget. 2016; 7(7):8078-89. PMC: 4884977. DOI: 10.18632/oncotarget.6978. View

Hashemi M, Sadeghi-Bojd S, Aryanezhad S, Rezaei M . Association of Endothelin-1 rs5370 G>T gene polymorphism with the risk of nephrotic syndrome in children. J Nephropathol. 2017; 6(3):138-143. PMC: 5607974. DOI: 10.15171/jnp.2017.24. View

He B, Lu P, Guan L, Li T, Zhang L, Zhu Q . Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method. Oncotarget. 2017; 8(61):103919-103930. PMC: 5732776. DOI: 10.18632/oncotarget.21865. View

Yang F, Lai X, Deng L, Liu X, Li J, Zeng S . Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children. Life Sci. 2014; 118(2):446-50. DOI: 10.1016/j.lfs.2014.04.010. View

Stark A, Brennecke J, Bushati N, Russell R, Cohen S . Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell. 2005; 123(6):1133-46. DOI: 10.1016/j.cell.2005.11.023. View

Shukla H, Mason J, Sabyah A . Identifying genetic markers associated with susceptibility to cardiovascular diseases. Future Sci OA. 2019; 5(1):FSO350. PMC: 6331704. DOI: 10.4155/fsoa-2018-0031. View

10.

Wenderfer S, Gaut J . Glomerular Diseases in Children. Adv Chronic Kidney Dis. 2017; 24(6):364-371. DOI: 10.1053/j.ackd.2017.09.005. View

11.

Xu H, Sun X, Qi T, Lin W, Liu N, Lou X . Multivariate dimensionality reduction approaches to identify gene-gene and gene-environment interactions underlying multiple complex traits. PLoS One. 2014; 9(9):e108103. PMC: 4178067. DOI: 10.1371/journal.pone.0108103. View

12.

He B, Lu C, Zheng G, He X, Wang M, Chen G . Combination therapeutics in complex diseases. J Cell Mol Med. 2016; 20(12):2231-2240. PMC: 5134672. DOI: 10.1111/jcmm.12930. View

13.

Uwaezuoke S . The role of novel biomarkers in childhood idiopathic nephrotic syndrome: a narrative review of published evidence. Int J Nephrol Renovasc Dis. 2017; 10:123-128. PMC: 5459980. DOI: 10.2147/IJNRD.S131869. View

14.

Wang C, Greenbaum L . Nephrotic Syndrome. Pediatr Clin North Am. 2018; 66(1):73-85. DOI: 10.1016/j.pcl.2018.08.006. View

15.

Gagliano S, Sengupta S, Sidore C, Maschio A, Cucca F, Schlessinger D . Relative impact of indels versus SNPs on complex disease. Genet Epidemiol. 2018; 43(1):112-117. PMC: 6330128. DOI: 10.1002/gepi.22175. View

16.

Varner J, Matory A, Gbadegesin R . Genetic Basis of Health Disparity in Childhood Nephrotic Syndrome. Am J Kidney Dis. 2018; 72(5 Suppl 1):S22-S25. PMC: 7077932. DOI: 10.1053/j.ajkd.2018.06.022. View

17.

De Miguel C, Speed J, Kasztan M, Gohar E, Pollock D . Endothelin-1 and the kidney: new perspectives and recent findings. Curr Opin Nephrol Hypertens. 2015; 25(1):35-41. PMC: 4698004. DOI: 10.1097/MNH.0000000000000185. View

18.

Ramirez-Bello J, Vargas-Alarcon G, Tovilla-Zarate C, Fragoso J . [Single nucleotide polymorphisms (SNPs): functional implications of regulatory-SNP (rSNP) and structural RNA (srSNPs) in complex diseases]. Gac Med Mex. 2013; 149(2):220-8. View

19.

Roy J, Mallick B . Altered gene expression in late-onset Alzheimer's disease due to SNPs within 3'UTR microRNA response elements. Genomics. 2017; 109(3-4):177-185. DOI: 10.1016/j.ygeno.2017.02.006. View

20.

Zhang R, Yang H, Zhu B, Yuan T, Peng Q, Lv J . Endothelin-1 rs9296344 associates with the susceptibility of childhood primary nephrotic syndrome. J Clin Lab Anal. 2020; 34(4):e23134. PMC: 7171328. DOI: 10.1002/jcla.23134. View