A Retrospective Cohort Study of Preoperative Lipid Indices and Their Impact on New-onset Diabetes After Liver Transplantation

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2020 Jan 26

PMID 31981248

Citations 3

Authors

Jing Liang

Xilu Yi

Mengjuan Xue

Xianying Chen

Xiaowu Huang

Qiman Sun

Ting Wang

Chenhe Zhao

Yinqiu Yang

Jian Gao

Jian Zhou

Jia Fan

Mingxiang Yu

Affiliations

Soon will be listed here.

Abstract

Background: The correlation between preoperative lipid profiles and new-onset diabetes after transplantation (NODAT) remains relatively unexplored in liver transplant recipients (LTRs). Thus, we aimed to investigate the preoperative lipid profiles in Chinese LTRs and evaluate the different influences of preoperative total cholesterol, total triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol on the development of NODAT in both sexes.

Methods: A total of 767 Chinese LTRs from Zhongshan Hospital were retrospectively evaluated. NODAT was defined according to the American Diabetes Association guidelines; the relationship between each preoperative lipid index and NODAT development was analyzed separately in men and women.

Results: Pretransplant hypotriglyceridemia was observed in 35.72% of the total LTRs. In men, only the preoperative TG level was significantly associated with incident NODAT after adjusting for potential confounders (hazard ratio 1.37, 95% confidence interval 1.13-1.66, P = .001). There was a nonlinear relationship between the preoperative TG level and NODAT risk. The risk of NODAT significantly increased with preoperative a TG level above 0.54 mmol/L (log-likelihood ratio test, P = .043). In women, no significant association was observed.

Conclusion: Among male LTRs, a higher preoperative TG level, even at a low level within the normal range, was significantly and nonlinearly associated with an increased risk of NODAT.

Citing Articles

Risk factors associated with diabetes after liver transplant.

Campos M, Riguetto C, Boin I, Neto A Arch Endocrinol Metab. 2022; 66(2):182-190.

PMID: 35315984 PMC: 9832889. DOI: 10.20945/2359-3997000000447.

Postoperative serum triglyceride levels in predicting risk of new-onset diabetes mellitus in patients following liver transplantation.

Wu Y, Jiang W, Yang X, Li W, Wan R, Lu L Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021; 50(2):239-244.

PMID: 34137229 PMC: 8710264. DOI: 10.3724/zdxbyxb-2021-0114.

A retrospective cohort study of preoperative lipid indices and their impact on new-onset diabetes after liver transplantation.

Liang J, Yi X, Xue M, Chen X, Huang X, Sun Q J Clin Lab Anal. 2020; 34(5):e23192.

PMID: 31981248 PMC: 7246365. DOI: 10.1002/jcla.23192.

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