Triterpenoid Saponin and Lignan Glycosides from the Traditional Medicine Elaeagnus Angustifolia Flowers and Their Cytotoxic Activities

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Jan 26

PMID 31979069

Citations 5

Authors

Jianxin Han

Xiaoyu Chen

Wei Liu

Hao Cui

Tao Yuan

Affiliations

Soon will be listed here.

Abstract

A new triterpenoid saponin, named terpengustifol A (), and two new lignan glucosides, phengustifols A and B ( and ), were isolated from the flowers of . Their structures were determined by the extensive analysis of the spectroscopic data (including NMR and HRMS) and ECD calculations. Compound possesses an unusual monoterpene ()-6-hydroxy-2,6-dimethylocta-2,7-dienoyl unit at C-21. Compounds and are a pair of diastereoisomers, while their aglycones are a pair of enantiomers. Compounds and exhibited moderate cytotoxic activities against A375 cell lines with IC values at 12.1 and 15.6 μM, respectively. This is firstly reported the triterpenoid saponin and lignans isolated from the flowers.

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