Vascular Uptake on F-sodium Fluoride Positron Emission Tomography: Precursor of Vascular Calcification?

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2020 Jan 25

PMID 31975332

Citations 9

Authors

Annemarie M den Harder

Jelmer M Wolterink

Jonas W Bartstra

Wilko Spiering

Sabine R Zwakenberg

Joline W Beulens

Riemer H J A Slart

Gert Luurtsema

Willem P Mali

Pim A de Jong

Affiliations

Soon will be listed here.

Abstract

Background: Microcalcifications cannot be identified with the present resolution of CT; however, F-sodium fluoride (F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification. The primary objective of this study was to assess whether F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification.

Methods And Results: The data of two longitudinal studies in which patients received a F-NaF PET-CT at baseline and after 6 months or 1-year follow-up were used. The target to background ratio (TBR) was measured on PET at baseline and CT calcification was quantified in the femoral arteries at baseline and follow-up. 128 patients were included. A higher TBR at baseline was associated with higher calcification mass at baseline and calcification progression (β = 1.006 [1.005-1.007] and β = 1.002 [1.002-1.003] in the studies with 6 months and 1-year follow-up, respectively). In areas without calcification at baseline and where calcification developed at follow-up, the TBR was .11-.13 (P < .001) higher compared to areas where no calcification developed.

Conclusion: The activity of F-NaF is related to the amount of calcification and calcification progression. In areas where calcification formation occurred, the TBR was slightly but significantly higher.

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