Gert Luurtsema
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Explore the profile of Gert Luurtsema including associated specialties, affiliations and a list of published articles.
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89
Citations
1583
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Recent Articles
1.
Helbert H, Deuther-Conrad W, de Haan M, Wenzel B, Luurtsema G, Szymanski W, et al.
EJNMMI Radiopharm Chem
. 2025 Feb;
10(1):7.
PMID: 39894871
Background: Through its central role in neurotransmission, the vesicular acetylcholine transporter (VAChT) is an increasingly valuable target for positron emission tomography (PET). VAChT ligands have been mostly derived from the...
2.
Salvi de Souza G, Furini C, Sijbesma J, Kominia M, Doorduin J, Giacobbo B, et al.
Mol Imaging Biol
. 2025 Jan;
27(1):89-98.
PMID: 39810067
Purpose: This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract of rats using positron emission tomography (PET) following oral administration of...
3.
Vermeiren M, Somsen J, Luurtsema G, Reesink F, Verwey N, Hempenius L, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):230.
PMID: 39427210
Background: Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer's disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in...
4.
Doze A, Fu Y, Di Donato M, Hilbers M, Luurtsema G, Elsinga P, et al.
Chem Sci
. 2024 Jul;
15(29):11557-11563.
PMID: 39055031
The light-induced photocycloaddition of 9,10-phenanthrenequinone (PQ) with electron-rich alkenes (ERA), known as the PQ-ERA reaction, is a highly attractive photoclick reaction characterized by its operational simplicity and high biocompatibility. One...
5.
Liu W, Mossel P, Schwach V, Slart R, Luurtsema G
Pharmaceuticals (Basel)
. 2023 Dec;
16(12).
PMID: 38139840
Adenosine triphosphate binding cassette (ABC) transporters are a broad family of membrane protein complexes that use energy to transport molecules across cells and/or intracellular organelle lipid membranes. Many drugs used...
6.
Slart R, Martinez-Lucio T, Boersma H, Borra R, Cornelissen B, Dierckx R, et al.
Semin Nucl Med
. 2023 Aug;
54(5):761-773.
PMID: 37640631
Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a...
7.
Mossel P, Arif W, Salvi de Souza G, Varela L, van der Weijden C, Boersma H, et al.
Eur J Nucl Med Mol Imaging
. 2023 Aug;
50(13):3917-3927.
PMID: 37552369
Introduction: P-glycoprotein (P-gp) is one of the most studied efflux transporters at the blood-brain barrier. It plays an important role in brain homeostasis by protecting the brain from a variety...
8.
Arif W, Elsinga P, Steenbakkers R, Noordzij W, Barazzuol L, Siang K, et al.
Clin Transl Radiat Oncol
. 2023 Jul;
42:100652.
PMID: 37415639
Background And Purpose: Previous pre-clinical research using [F]FDG-PET has shown that whole-brain photon-based radiotherapy can affect brain glucose metabolism. This study, aimed to investigate how these findings translate into regional...
9.
Salvi de Souza G, Mantovani D, Mossel P, Haarman B, Marques da Silva A, Boersma H, et al.
J Control Release
. 2023 Apr;
357:591-605.
PMID: 37031742
The oral route is the most widely used and preferable way of drug administration. Several pharmacokinetic processes play a role in the distribution of administered drugs. Therefore, accurate quantification of...
10.
van der Weijden C, Mossel P, Bartels A, Dierckx R, Luurtsema G, Lammertsma A, et al.
Eur J Nucl Med Mol Imaging
. 2023 Jan;
50(6):1636-1650.
PMID: 36651951
Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic PET data of the brain. However, the invasive character of arterial sampling prevents its widespread clinical application. Several...