Correlation Between Nitric Oxide Content in Exhaled Breath Condensate and the Severity of Acute Respiratory Distress Syndrome

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Jan 23

PMID 31966575

Citations 3

Authors

Kankai Tang

Xueping Shao

Fengqi Liu

Bingnan Zhu

Zhaohui Dong

Wei Xu

Qing Yang

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) can induce necrosis and detachment of branchial epithelium, aggregate inflammation and induce acute respiratory distress syndrome (ARDS). The detection of NO in exhaled breath condensate (EBC) has not been widely applied in evaluating ARDS condition. This study thus tested NO in EBC of ARDS patients, in order to provide non-invasive method to monitor disease condition of ARDS. ARDS patients in ICU of our hospital were recruited in parallel with healthy controls. NO contents in EBC and serum were measured in both control group and ARDS patients before/after treatment, and between survived and dead patients. APACHE II score, PaO/FiO, and PaO were also quantified and analyzed for their correlation with NO contents. Correlation between EBC and serum NO contest was also analyzed. ARDS patients had significantly higher EBC/serum NO contents before treatment compared to control. NO levels were remarkably decreased after treatment (P<0.05). Survival patients had decreased APACHEII score, and EBC/serum NO, plus elevated PaO/FiO, and PaO after treatment. Dead patients had elevated APACHEII score, EBC/serum NO with prolonged treatment, plus decreased PaO/FiO, and PaO (P<0.05). EBC/serum NO in ARDS patients were positively correlated with APACHE II score, and negatively correlated with PaO/FiO, and PaO (P<0.05). NO level in EBC was positively correlated with serum level in ARDS patients (P<0.05). The detection of EBC NO content can reflect hypoxia and disease condition of ARDS patients, and benefits treatment efficacy evaluation and prognostic judgement. EBC NO can replace serum NO due to satisfactory correlation.

Citing Articles

Biomonitoring Environmental Exposure in Syrian Refugees in Lebanon.

Alaouie M, Troisi G Epidemiologia (Basel). 2024; 5(2):309-317.

PMID: 38920756 PMC: 11203224. DOI: 10.3390/epidemiologia5020021.

Role of Olive Bioactive Compounds in Respiratory Diseases.

Vijakumaran U, Goh N, Razali R, Abdullah N, Yazid M, Sulaiman N Antioxidants (Basel). 2023; 12(6).

PMID: 37371870 PMC: 10295110. DOI: 10.3390/antiox12061140.

Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems.

Guimaraes L, Rossini C, Lameu C Nitric Oxide. 2021; 111-112:64-71.

PMID: 33831567 PMC: 8021449. DOI: 10.1016/j.niox.2021.04.003.

References

Mazur W, Stark H, Sovijarvi A, Myllarniemi M, Kinnula V . Comparison of 8-isoprostane and interleukin-8 in induced sputum and exhaled breath condensate from asymptomatic and symptomatic smokers. Respiration. 2009; 78(2):209-16. DOI: 10.1159/000206010. View

Ciprandi G, Tosca M, Capasso M . High exhaled nitric oxide levels may predict bronchial reversibility in allergic children with asthma or rhinitis. J Asthma. 2012; 50(1):33-8. DOI: 10.3109/02770903.2012.740119. View

Udwadia Z . ARDS: predicting mortality and improving survival. J Assoc Physicians India. 2004; 51:849-50. View

Kazani S, Israel E . Exhaled breath condensates in asthma: diagnostic and therapeutic implications. J Breath Res. 2011; 4(4):047001. DOI: 10.1088/1752-7155/4/4/047001. View

Wallet F, Delannoy B, Haquin A, Debord S, Leray V, Bourdin G . Evaluation of recruited lung volume at inspiratory plateau pressure with PEEP using bedside digital chest X-ray in patients with acute lung injury/ARDS. Respir Care. 2013; 58(3):416-23. DOI: 10.4187/respcare.01893. View

Liu J, Thomas P . Exhaled breath condensate as a method of sampling airway nitric oxide and other markers of inflammation. Med Sci Monit. 2005; 11(8):MT53-62. View

Karnik N, Gupta A . Predicting Survival in ARDS. J Assoc Physicians India. 2018; 63(11):11-3. View

Ahmadzai H, Huang S, Hettiarachchi R, Lin J, Thomas P, Zhang Q . Exhaled breath condensate: a comprehensive update. Clin Chem Lab Med. 2013; 51(7):1343-61. DOI: 10.1515/cclm-2012-0593. View

Grawe E, Bennett S, Hurford W . Early Paralysis for the Management of ARDS. Respir Care. 2016; 61(6):830-8. DOI: 10.4187/respcare.04734. View

10.

de Luis Cabezon N, Sanchez Castro I, Bengoetxea Uriarte U, Rodrigo Casanova M, Garcia Pena J, Aguilera Celorrio L . [Acute respiratory distress syndrome: a review of the Berlin definition]. Rev Esp Anestesiol Reanim. 2014; 61(6):319-27. DOI: 10.1016/j.redar.2014.02.007. View

11.

Ratnawati , Morton J, Henry R, Thomas P . Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide. Pediatr Pulmonol. 2006; 41(10):929-36. DOI: 10.1002/ppul.20469. View

12.

Silkoff P, Erzurum S, Lundberg J, George S, Marczin N, Hunt J . ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate. Proc Am Thorac Soc. 2006; 3(2):131-45. DOI: 10.1513/pats.200406-710ST. View

13.

Gattinoni L, Quintel M . How ARDS should be treated. Crit Care. 2016; 20:86. PMC: 4822276. DOI: 10.1186/s13054-016-1268-7. View

14.

Liu D, Luo G, Luo C, Wang T, Sun G, Hei Z . Changes in the Concentrations of Mediators of Inflammation and Oxidative Stress in Exhaled Breath Condensate During Liver Transplantation and Their Relations With Postoperative ARDS. Respir Care. 2015; 60(5):679-88. DOI: 10.4187/respcare.03311. View

15.

Bernard G . Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med. 2005; 172(7):798-806. PMC: 2718401. DOI: 10.1164/rccm.200504-663OE. View

16.

Gessner C, Hammerschmidt S, Kuhn H, Seyfarth H, Sack U, Engelmann L . Exhaled breath condensate acidification in acute lung injury. Respir Med. 2003; 97(11):1188-94. DOI: 10.1016/s0954-6111(03)00225-7. View

17.

Kamiyama I, Kohno M, Kamiya K, Nakamura H, Sawafuji M, Kobayashi K . A new technique of bronchial microsampling and proteomic analysis of epithelial lining fluid in a rat model of acute lung injury. Mol Immunol. 2014; 59(2):217-25. DOI: 10.1016/j.molimm.2014.02.013. View

18.

Eddleston M, Wilks M, Buckley N . Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review. QJM. 2003; 96(11):809-24. PMC: 1948029. DOI: 10.1093/qjmed/hcg137. View

19.

Konstantinidi E, Lappas A, Tzortzi A, Behrakis P . Exhaled Breath Condensate: Technical and Diagnostic Aspects. ScientificWorldJournal. 2015; 2015:435160. PMC: 4461795. DOI: 10.1155/2015/435160. View

20.

Kahn N, Meister M, Eberhardt R, Muley T, Schnabel P, Bender C . Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid. J Thorac Oncol. 2012; 7(6):1001-8. DOI: 10.1097/JTO.0b013e31824fe921. View