A treatise on Endothelial Biology and Exosomes: Homage to Theresa Maria Listowska Whiteside

Overview

Journal HNO

Specialty Otorhinolaryngology

Date 2020 Jan 23

PMID 31965194

Citations 2

Authors

N Ludwig

M T Lotze

Affiliations

Soon will be listed here.

Abstract

Exosomes are the current primary research focus of Dr. Theresa L. Whiteside. They are key mediators of intercellular communication in the head and neck, as well as other sites. Their effects in the tumor microenvironment are manifold and include suppression of immunity, promotion of angiogenesis, enabling of metastasis, as well as reprogramming of fibroblasts and mesenchymal stromal cells. The aim of this communication is to summarize Dr. Whiteside's contribution to the field of exosome research and details the interactions of exosomes with endothelial cells leading to recent findings on how to target endothelial cells using exosomes as a therapeutic approach.

Citing Articles

A Rapid Exosome Isolation Using Ultrafiltration and Size Exclusion Chromatography (REIUS) Method for Exosome Isolation from Melanoma Cell Lines.

Shu S, Allen C, Benjamin-Davalos S, Koroleva M, MacFarland D, Minderman H Methods Mol Biol. 2021; 2265:289-304.

PMID: 33704723 PMC: 8865195. DOI: 10.1007/978-1-0716-1205-7_22.

Potential Roles of Tumor Cell- and Stroma Cell-Derived Small Extracellular Vesicles in Promoting a Pro-Angiogenic Tumor Microenvironment.

Ludwig N, Rubenich D, Zareba L, Siewiera J, Pieper J, Braganhol E Cancers (Basel). 2020; 12(12).

PMID: 33276428 PMC: 7760552. DOI: 10.3390/cancers12123599.

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