T-cell Markers in Tumor-infiltrating Lymphocytes of Head and Neck Cancer
Overview
Affiliations
Fresh suspensions of tumor-infiltrating lymphocytes (TIL) from 16 patients with squamous cell carcinoma of the head and neck (SCCHN) were examined for T-cell markers including CD4 (helper-inducer), CD8 (cytotoxic-suppressor), natural killer (NK) cell, and activation surface markers using monoclonal antibodies and two-color flow cytometry. Two of 8 (25%) patients with a CD4/CD8 ratio of less than 1 developed cervical lymph node metastases; none had extracapsular spread. Six of 8 (75%) patients with a CD4/CD8 ratio of greater than 1 developed cervical metastases; 5 of 6 (83%) exhibited extracapsular spread. An increased CD4/CD8 ratio was attributable to a decrease in CD8+ cells. A CD4/CD8 ratio of greater than 1 may be a useful prognostic indicator of the development of cervical metastases.
Sung Y, Kim M, Lee Y Head Neck. 2021; 43(5):1581-1591.
PMID: 33533145 PMC: 8247849. DOI: 10.1002/hed.26621.
Jin W, Erbe A, Schwarz C, Jaquish A, Anderson B, Sriramaneni R Front Immunol. 2020; 11:591139.
PMID: 33281820 PMC: 7689006. DOI: 10.3389/fimmu.2020.591139.
A treatise on endothelial biology and exosomes: homage to Theresa Maria Listowska Whiteside.
Ludwig N, Lotze M HNO. 2020; 68(2):71-79.
PMID: 31965194 DOI: 10.1007/s00106-019-00803-1.
Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer.
Judd N, Allen C, Winkler A, Uppaluri R Otolaryngol Head Neck Surg. 2012; 147(3):493-500.
PMID: 22434099 PMC: 6346425. DOI: 10.1177/0194599812442037.
Berinstein N, Wolf G, Naylor P, Baltzer L, Egan J, Brandwein H Cancer Immunol Immunother. 2011; 61(6):771-82.
PMID: 22057678 PMC: 5300054. DOI: 10.1007/s00262-011-1134-z.