Contribution of Sex and Autoantibodies to Microangiopathy Assessed by Nailfold Videocapillaroscopy in Systemic Sclerosis: A Systematic Review of the Literature

Overview

Journal Arthritis Care Res (Hoboken)

Specialty Rheumatology

Date 2020 Jan 22

PMID 31962005

Citations 3

Authors

Nina M van Leeuwen

Jacopo Ciaffi

Jan W Schoones

Tom W J Huizinga

Jeska K de Vries-Bouwstra

Affiliations

Soon will be listed here.

Abstract

Objective: Microangiopathy and dysregulation of the immune system play important roles in the pathogenesis of systemic sclerosis (SSc). Factors that trigger vascular injury in SSc have not been elucidated so far. We undertook this study to evaluate whether sex or expression of specific antinuclear autoantibodies might associate with the degree of microangiopathy through performance of a systematic review that summarizes what is known about these associations.

Methods: A standardized search of PubMed, Embase, Web of Science, and the Cochrane Library were performed to identify studies that described autoantibodies in SSc patients and microangiopathy and, for the second search, those that described sex and microangiopathy.

Results: We included 11 studies that described the relationship between SSc-specific autoantibodies and microangiopathy and 6 studies that reported on the association between sex and microangiopathy. Contradictory results were found on the association between SSc-specific autoantibodies and microangiopathy, and no association was found between sex and microangiopathy based on the current literature.

Conclusion: Based on this review of the literature, we can conclude that sex does not seem to influence degree of microangiopathy in SSc, while results on association between SSc-specific autoantibodies and degree of microangiopathy were inconclusive.

Citing Articles

Active pattern on nailfold capillaroscopy in a patient with systemic sclerosis.

Ye W, Cao L, Zhou Y, Xue Y, Wan W, Zou H Rheumatol Immunol Res. 2023; 4(3):171-172.

PMID: 37781676 PMC: 10538595. DOI: 10.2478/rir-2023-0025.

Specific Autoantibodies and Microvascular Damage Progression Assessed by Nailfold Videocapillaroscopy in Systemic Sclerosis: Are There Peculiar Associations? An Update.

Hysa E, Campitiello R, Sammori S, Gotelli E, Cere A, Pesce G Antibodies (Basel). 2023; 12(1).

PMID: 36648887 PMC: 9844325. DOI: 10.3390/antib12010003.

Capillaroscopy and Immunological Profile in Systemic Sclerosis.

Lambova S, Kurteva E, Dzhambazova S, Vasilev G, Kyurkchiev D, Geneva-Popova M Life (Basel). 2022; 12(4).

PMID: 35454989 PMC: 9024594. DOI: 10.3390/life12040498.

References

Avouac J, Pezet S, Gonzalez V, Baudoin L, Cauvet A, Ruiz B . Estrogens Counteract the Profibrotic Effects of TGF-β and their Inhibition Exacerbates Experimental Dermal Fibrosis. J Invest Dermatol. 2019; 140(3):593-601.e7. DOI: 10.1016/j.jid.2019.07.719. View

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

Aida-Yasuoka K, Peoples C, Yasuoka H, Hershberger P, Thiel K, Cauley J . Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis. Arthritis Res Ther. 2013; 15(1):R10. PMC: 3672719. DOI: 10.1186/ar4140. View

Ferri C, Valentini G, Cozzi F, Sebastiani M, Michelassi C, La Montagna G . Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine (Baltimore). 2002; 81(2):139-53. DOI: 10.1097/00005792-200203000-00004. View

Cutolo M, Pizzorni C, Tuccio M, Burroni A, Craviotto C, Basso M . Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology (Oxford). 2004; 43(6):719-26. DOI: 10.1093/rheumatology/keh156. View

Ciaffi J, van Leeuwen N, Huizinga T, de Vries-Bouwstra J . Cumulative endogenous estrogen exposure is not associated with severity of peripheral microangiopathy in patients with systemic sclerosis. Clin Exp Rheumatol. 2019; 37 Suppl 119(4):82-87. View

MARICQ H, HARPER F, Khan M, Tan E, LeRoy E . Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease. Clin Exp Rheumatol. 1983; 1(3):195-205. View

Cutolo M, Melsens K, Wijnant S, Ingegnoli F, Thevissen K, De Keyser F . Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal. Autoimmun Rev. 2018; 17(4):344-352. DOI: 10.1016/j.autrev.2017.11.025. View

Reveille J, Fischbach M, McNearney T, Friedman A, Aguilar M, Lisse J . Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. Semin Arthritis Rheum. 2001; 30(5):332-46. DOI: 10.1053/sarh.2001.20268. View

10.

Peoples C, Medsger Jr T, Lucas M, Rosario B, Feghali-Bostwick C . Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes. J Scleroderma Relat Disord. 2017; 1(2):177-240. PMC: 5726425. DOI: 10.5301/jsrd.5000209. View

11.

Smith V, Decuman S, Sulli A, Bonroy C, Piettte Y, Deschepper E . Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study. Ann Rheum Dis. 2012; 71(10):1636-9. DOI: 10.1136/annrheumdis-2011-200780. View

12.

Volgman A, Merz C, Aggarwal N, Bittner V, Bunch T, Gorelick P . Sex Differences in Cardiovascular Disease and Cognitive Impairment: Another Health Disparity for Women?. J Am Heart Assoc. 2019; 8(19):e013154. PMC: 6806032. DOI: 10.1161/JAHA.119.013154. View

13.

Bregenzer N, Distler O, Meyringer R, Scholmerich J, Muller-Ladner U, Lock G . Doppler ultrasound identifies increased resistive indices in SSc. Ann Rheum Dis. 2003; 63(1):109-10. PMC: 1754714. DOI: 10.1136/ard.2003.009118. View

14.

De Santis M, Ceribelli A, Cavaciocchi F, Crotti C, Massarotti M, Belloli L . Nailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement. Auto Immun Highlights. 2016; 7(1):5. PMC: 4754208. DOI: 10.1007/s13317-016-0077-y. View

15.

Sulli A, Ruaro B, Smith V, Pizzorni C, Zampogna G, Gallo M . Progression of nailfold microvascular damage and antinuclear antibody pattern in systemic sclerosis. J Rheumatol. 2013; 40(5):634-9. DOI: 10.3899/jrheum.121089. View

16.

Fraenkel L, Zhang Y, Chaisson C, Evans S, Wilson P, Felson D . The association of estrogen replacement therapy and the Raynaud phenomenon in postmenopausal women. Ann Intern Med. 1998; 129(3):208-11. DOI: 10.7326/0003-4819-129-3-199808010-00009. View

17.

Koenig M, Joyal F, Fritzler M, Roussin A, Abrahamowicz M, Boire G . Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic.... Arthritis Rheum. 2008; 58(12):3902-12. DOI: 10.1002/art.24038. View

18.

Cutolo M, Soldano S, Smith V . Pathophysiology of systemic sclerosis: current understanding and new insights. Expert Rev Clin Immunol. 2019; 15(7):753-764. DOI: 10.1080/1744666X.2019.1614915. View

19.

Okroglic S, Widmann C, Urbach H, Scheltens P, Heneka M . Clinical symptoms and risk factors in cerebral microangiopathy patients. PLoS One. 2013; 8(2):e53455. PMC: 3564848. DOI: 10.1371/journal.pone.0053455. View

20.

Rosato E, Gigante A, Barbano B, Cianci R, Molinaro I, Pisarri S . In systemic sclerosis macrovascular damage of hands digital arteries correlates with microvascular damage. Microvasc Res. 2011; 82(3):410-5. DOI: 10.1016/j.mvr.2011.07.009. View