Evaluation of the Physical and Antifungal Effects of Chlorhexidine Diacetate Incorporated into Polymethyl Methacrylate

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2020 Jan 16

PMID 31939520

Citations 5

Authors

Caroline Vieira Maluf

Luciana Vieira Peroni

Livia Rodrigues Menezes

Wagner Coutinho

Eduardo Jose Veras Lourenco

Daniel de Moraes Telles

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to evaluate the physical properties and antifungal activities of polymethyl methacrylate (PMMA) acrylic resins after the incorporation of chlorhexidine diacetate salt (CDA).

Methodology: First, acrylic resin specimens were fabricated with Vipi Cor® and DuraLay® resins with and without the incorporation of 0.5%, 1.0% or 2.0% CDA. The residual monomer and CDA release were measured at intervals ranging from 2 hours to 28 days using ultraviolet spectrometry combined with high-performance liquid chromatography. The antifungal activity against C. albicans was evaluated with the agar diffusion method. Fourier transform infrared spectroscopy was used to analyze the degree of resin conversion. Finally, the water sorption values of the resins were also measured.

Results: The incorporated CDA concentration significantly changed the rate of CDA release (p<0.0001); however, the brand of the material appeared to have no significant influence on drug release. Subsequently, the inhibition zones were compared between the tested groups and within the same brand, and only the comparisons between the CDA 2% and CDA 1% groups and between the CDA 1% and CDA 0.5% groups failed to yield significant differences. Regarding the degrees of conversion, the differences were not significant and were lower only in the CDA 2% groups. Water sorption was significantly increased at the 1.0% and 2.0% concentrations.

Conclusions: We concluded that the incorporation of CDA into PMMA-based resins enabled the inhibition of C. albicans growth rate, did not alter the degrees of conversion of the tested resins and did not change the release of residual monomers.

Citing Articles

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Antifungal Polymeric Materials and Nanocomposites.

Ntow-Boahene W, Cook D, Good L Front Bioeng Biotechnol. 2022; 9:780328.

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