New Form of Administering Chlorhexidine for Treatment of Denture-induced Stomatitis

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2011 Jul 15

PMID 21753884

Citations 8

Authors

Soukaina Ryalat

Rula Darwish

Wala Amin

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans.

Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a "well" technique on Saboraud culture medium inoculated with a resistant strain of C. albicans.

Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans.

Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.

Citing Articles

Evaluation of polymethyl-methacrylate and acetal denture base resins processed by two different techniques before and after nano-chlorohexidine surface treatment.

Fathy S, Abdel-Halim M, El-Safty S, El-Ganiny A BMC Oral Health. 2023; 23(1):985.

PMID: 38066495 PMC: 10709906. DOI: 10.1186/s12903-023-03718-0.

An Innovative Polymeric Platform for Controlled and Localized Drug Delivery.

Elbjorn M, Provencio J, Phillips P, Sainz J, Harrison N, Rocco D Pharmaceutics. 2023; 15(7).

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Understanding the Mechanical, Surface, and Color Behavior of Oral Bioactive Prosthetic Polymers under Biodegradation Processes.

Neves C, Costa J, Portugal J, Bettencourt A Polymers (Basel). 2023; 15(11).

PMID: 37299348 PMC: 10255246. DOI: 10.3390/polym15112549.

Prospects on Tuning Bioactive and Antimicrobial Denture Base Resin Materials: A Narrative Review.

Al-Dulaijan Y, Balhaddad A Polymers (Basel). 2023; 15(1).

PMID: 36616404 PMC: 9823688. DOI: 10.3390/polym15010054.

How Effective Are Antimicrobial Agents on Preventing the Adhesion of to Denture Base Acrylic Resin Materials? A Systematic Review.

Bajunaid S Polymers (Basel). 2022; 14(5).

PMID: 35267731 PMC: 8912396. DOI: 10.3390/polym14050908.

References

Lamb D, Martin M . An in vitro and in vivo study of the effect of incorporation of chlorhexidine into autopolymerizing acrylic resin plates upon the growth of Candida albicans. Biomaterials. 1983; 4(3):205-9. DOI: 10.1016/0142-9612(83)90012-1. View

Sadamori S, Kotani H, Hamada T . The usage period of dentures and their residual monomer contents. J Prosthet Dent. 1992; 68(2):374-6. DOI: 10.1016/0022-3913(92)90349-f. View

Urban V, Cass Q, Oliveira R, Giampaolo E, Machado A . Development and application of methods for determination of residual monomer in dental acrylic resins using high performance liquid chromatography. Biomed Chromatogr. 2005; 20(4):369-76. DOI: 10.1002/bmc.575. View

WOLCOTT R, PAFFENBARGER G, SCHOONOVER I . Direct resinous filling materials: temperature rise during polymerization. J Am Dent Assoc. 1951; 42(3):253-63. DOI: 10.14219/jada.archive.1951.0055. View

Brook I, van Noort R . Drug release from acrylic polymers via channels and cracks: in vitro studies with hydrocortisone. Biomaterials. 1985; 6(4):281-5. DOI: 10.1016/0142-9612(85)90027-4. View

Bonesvoll P, Lokken P, Rolla G, Paus P . Retention of chlorhexidine in the human oral cavity after mouth rinses. Arch Oral Biol. 1974; 19(3):209-12. DOI: 10.1016/0003-9969(74)90263-5. View

Koray M, Ak G, Kurklu E, Issever H, Tanyeri H, Kulekci G . Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis. Oral Dis. 2005; 11(5):309-13. DOI: 10.1111/j.1601-0825.2005.01124.x. View

Addy M, Thaw M . In vitro studies into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic. J Biomed Mater Res. 1982; 16(2):145-57. DOI: 10.1002/jbm.820160207. View

Thurmond J, Brown A, Sims R, Ferretti G, Raybould T, Lillich T . Oral Candida albicans in bone marrow transplant patients given chlorhexidine rinses: occurrence and susceptibilities to the agent. Oral Surg Oral Med Oral Pathol. 1991; 72(3):291-5. DOI: 10.1016/0030-4220(91)90217-z. View

10.

Caul H, SWEENEY W, PAFFENBARGER G . Relationship between residual monomer and some properties of self-curing dental resins. J Am Dent Assoc. 1956; 53(1):60-3. DOI: 10.14219/jada.archive.1956.0144. View

11.

Tobgi R, Samaranayake L, MacFarlane T . Adhesion of Candida albicans to buccal epithelial cells exposed to chlorhexidine gluconate. J Med Vet Mycol. 1987; 25(5):335-8. View

12.

Budtz-Jorgensen E . Etiology, pathogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol Scand. 1990; 48(1):61-9. DOI: 10.3109/00016359009012735. View

13.

Baillie G, Douglas L . Candida biofilms and their susceptibility to antifungal agents. Methods Enzymol. 1999; 310:644-56. DOI: 10.1016/s0076-6879(99)10050-8. View

14.

MacNeill S, Rindler E, Walker A, Brown A, Cobb C . Effects of tetracycline hydrochloride and chlorhexidine gluconate on Candida albicans. An in vitro study. J Clin Periodontol. 1997; 24(10):753-60. DOI: 10.1111/j.1600-051x.1997.tb00193.x. View

15.

Austin A, Basker R . The level of residual monomer in acrylic denture base materials with particular reference to a modified method of analysis. Br Dent J. 1980; 149(10):281-6. DOI: 10.1038/sj.bdj.4804511. View

16.

Chai X, Hou Q, Schork F . Determination of residual monomer in polymer latex by full evaporation headspace gas chromatography. J Chromatogr A. 2004; 1040(2):163-7. DOI: 10.1016/j.chroma.2004.04.024. View

17.

Friedman M, Golomb G . New sustained release dosage form of chlorhexidine for dental use. I. Development and kinetics of release. J Periodontal Res. 1982; 17(3):323-8. DOI: 10.1111/j.1600-0765.1982.tb01160.x. View

18.

Samaranayake L . Oral mycoses in HIV infection. Oral Surg Oral Med Oral Pathol. 1992; 73(2):171-80. DOI: 10.1016/0030-4220(92)90191-r. View

19.

Smith D, BAINS M . The detection and estimation of residual monomer in polymethyl methacrylate. J Dent Res. 1956; 35(1):16-24. DOI: 10.1177/00220345560350010901. View

20.

Riggs P, Braden M, Patel M . Chlorhexidine release from room temperature polymerising methacrylate systems. Biomaterials. 2000; 21(4):345-51. DOI: 10.1016/s0142-9612(99)00187-8. View