Heme Oxygenase-1 (HO-1) Alleviates Vascular Restenosis After Balloon Injury in a Rabbit Carotid Artery Model

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Jan 16

PMID 31938360

Citations 1

Authors

Danan Liu

Xiangang Mo

Hongming Zhang

Lirong Wu

Juan Tan

Jincui Xiao

Zheng Qin

Affiliations

Soon will be listed here.

Abstract

Percutaneous coronary intervention (PCI) is used commonly for coronary artery disease (CAD); however, restenosis is a proliferative response and frequent sequela to this treatment. Although the introduction of drug-eluting stents has convincingly reduced the incidence of vascular restenosis, restenosis remains a problem. The present study was designed to investigate the effects of the heme oxygenase-1 (HO-1) on restenosis formation after balloon injury in a rabbit carotid artery model. We found that involvement of the HO-1 in defensive restenosis formation was independent of the levels of blood lipid. Activation of HO-1 induced by chlorhematin treatment alleviated vascular restenosis after balloon injury in a rabbit carotid artery model, whereas inhibition of HO-1 by zinc protoporphyrin treatment exacerbated restenosis formation. Furthermore, overexpression of HO-1 inhibited nuclear factor kappa B subunit 1 (NF-кB) activity and decreased tumor necrosis factor-alpha (TNF-α) and endothelin 1 (ET-1) expression. In conclusion, our study provides preliminary data suggesting that HO-1 alleviates vascular restenosis after balloon injury in a rabbit carotid artery model by inhibiting NF-кB, TNF-α and ET-1 expression, indicating induction of HO-1 activation may be a feasible therapeutic target for treating vessels resistant to restenosis.

Citing Articles

HS attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty.

Ling K, Zhou W, Guo Y, Hu G, Chu J, Xie F Exp Biol Med (Maywood). 2020; 246(2):226-239.

PMID: 32996350 PMC: 7871122. DOI: 10.1177/1535370220961038.

References

Jiang F, Jiang R, Zhu X, Zhang X, Zhan Z . Genipin inhibits TNF-α-induced vascular smooth muscle cell proliferation and migration via induction of HO-1. PLoS One. 2013; 8(8):e74826. PMC: 3754946. DOI: 10.1371/journal.pone.0074826. View

Tan Y, Wang Q, She Y, Bi X, Zhao B . Ketamine reduces LPS-induced HMGB1 via activation of the Nrf2/HO-1 pathway and NF-κB suppression. J Trauma Acute Care Surg. 2015; 78(4):784-92. DOI: 10.1097/TA.0000000000000588. View

Buccheri D, Piraino D, Andolina G, Cortese B . Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment. J Thorac Dis. 2016; 8(10):E1150-E1162. PMC: 5107494. DOI: 10.21037/jtd.2016.10.93. View

Denes L, Entz L, Jancsik V . Restenosis and therapy. Int J Vasc Med. 2012; 2012:406236. PMC: 3303576. DOI: 10.1155/2012/406236. View

Kwon J, Joung H, Kim Y, Shim Y, Ahn Y, Jeong M . Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells. Atherosclerosis. 2012; 225(1):41-9. DOI: 10.1016/j.atherosclerosis.2012.07.040. View

Clerigues V, Murphy C, Guillen M, Alcaraz M . Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia. Clin Sci (Lond). 2013; 125(2):99-108. DOI: 10.1042/CS20120491. View

Kranzhofer R, Schmidt J, Pfeiffer C, Hagl S, Libby P, Kubler W . Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999; 19(7):1623-9. DOI: 10.1161/01.atv.19.7.1623. View

Ma T, Chen T, Li P, Ye Z, Zhai W, Jia L . Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. Exp Eye Res. 2016; 146:318-329. DOI: 10.1016/j.exer.2016.02.013. View

Rai A, Bahremand M, Saidi M, Jalili Z, Salehi N, Assareh M . The Value of Pre- and Post-Stenting Fractional Flow Reserve for Predicting Mid-Term Stent Restenosis Following Percutaneous Coronary Intervention (PCI). Glob J Health Sci. 2016; 8(7):240-44. PMC: 4965670. DOI: 10.5539/gjhs.v8n7p240. View

10.

Billack B . Macrophage activation: role of toll-like receptors, nitric oxide, and nuclear factor kappa B. Am J Pharm Educ. 2006; 70(5):102. PMC: 1637021. DOI: 10.5688/aj7005102. View

11.

Takano M, Ohba T, Inami S, Seimiya K, Sakai S, Mizuno K . Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation. Eur Heart J. 2006; 27(18):2189-95. DOI: 10.1093/eurheartj/ehl181. View

12.

Hillegass W . Diabetes is not sufficient justification for IIb/IIIa use in percutaneous coronary intervention. Catheter Cardiovasc Interv. 2015; 86(3):376-7. DOI: 10.1002/ccd.26130. View

13.

Kuchulakanti P, Chu W, Torguson R, Ohlmann P, Rha S, Clavijo L . Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation. 2006; 113(8):1108-13. DOI: 10.1161/CIRCULATIONAHA.105.600155. View

14.

Yamasaki K, Asai T, Shimizu M, Aoki M, Hashiya N, Sakonjo H . Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Ther. 2003; 10(4):356-64. DOI: 10.1038/sj.gt.3301875. View

15.

Goebeler M, Gillitzer R, Kilian K, Utzel K, Brocker E, Rapp U . Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood. 2001; 97(1):46-55. DOI: 10.1182/blood.v97.1.46. View

16.

Chen S, Ding Y, Tao W, Zhang W, Liang T, Liu C . Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem Toxicol. 2012; 50(9):3025-31. DOI: 10.1016/j.fct.2012.06.006. View

17.

Wang C, Chau L . Heme oxygenase-1 in cardiovascular diseases: molecular mechanisms and clinical perspectives. Chang Gung Med J. 2010; 33(1):13-24. View

18.

Lee C, Yen M . Nitric oxide and carbon monoxide, collaborative and competitive regulators of hypertension. Chang Gung Med J. 2009; 32(1):12-21. View

19.

Liu B, Qian J . Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury. Int J Clin Exp Med. 2016; 8(11):19867-73. PMC: 4723742. View

20.

Pae H, Oh G, Lee B, Rim J, Kim Y, Chung H . 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis. 2005; 187(2):274-84. DOI: 10.1016/j.atherosclerosis.2005.09.010. View