MicroRNA-940 Inhibits Epithelial-mesenchymal Transition of Glioma Cells Via Targeting ZEB2

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2020 Jan 15

PMID 31934283

Citations 17

Authors

Ran Xu

Fengqi Zhou

Tianfu Yu

Guanhua Xu

Junxia Zhang

Yingyi Wang

Lin Zhao

Ning Liu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs have been found ectopically expressed in many cancers and play essential roles in tumor EMT progress. Recent studies identified decreased miR-940 expression in glioma cells and may serve as a tumor-suppressor. However, whether miR-940 involve in glioma EMT remain poorly understood. Here we confirmed that miR-940 was significantly reduced in glioma cells and tissues. Introduction of miR-940 dramatically suppressed invasion and migration of glioma cells. Gain-of-function experiments showed ZEB2 as a direct target of miR-940, knockdown of ZEB2 evidently repressed invasive capacity of glioma cells through EMT. Moreover, reintroduction of ZEB2 effectively reversed the tumor suppressive effect of miR-940 treatment. In vivo study showed reduced tumor cell motion in miR-940-injected groups. Spearman's correlation analysis indicated inversely correlated expression of ZEB2 and miR-940 in gliomas and NBTs. Altogether, miR-940-ZEB2 cascade may play important roles in glioma cells invasion and EMT progression, and might provide new therapeutic approaches for better outcomes of GBM patients.

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