The Role of MiRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2017 Jul 13

PMID 28698530

Citations 28

Authors

Sasha Beyer

Jessica Fleming

Wei Meng

Rajbir Singh

S Jaharul Haque

Arnab Chakravarti

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The dysregulation of miRNA plays a pivotal role in cancer tumorigenesis, including the development and progression of gliomas. Their small size, stability and ability to target multiple oncogenes have simultaneously distinguished miRNAs as attractive candidates for biomarkers and novel therapeutic targets for glioma patients. In this review, we summarize the most frequently cited miRNAs known to contribute to gliomagenesis and progression by regulating the defining hallmarks of gliomas, including angiogenesis, invasion, and cell metabolism. We also discuss their promising potential as prognostic and predictive biomarkers and novel therapeutic targets, in addition to the challenges that must be overcome before their translation from bench to bedside.

Citing Articles

Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma - A Cross-Sectional Study.

Dwianingsih E, Hartanto R, Safitri S, Krisnugraha Y, Sianipar C, Basuki E F1000Res. 2025; 13():1361.

PMID: 39801574 PMC: 11725040. DOI: 10.12688/f1000research.153731.1.

The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application.

Mafi A, Mannani R, Khalilollah S, Hedayati N, Salami R, Rezaee M Cell Mol Neurobiol. 2023; 43(7):3277-3299.

PMID: 37414973 PMC: 11409989. DOI: 10.1007/s10571-023-01385-x.

Angiogenesis and Its Targeting in Glioblastoma with Focus on Clinical Approaches.

Daneshimehr F, Barabadi Z, Abdolahi S, Soleimani M, Verdi J, Ebrahimi-Barough S Cell J. 2022; 24(10):555-568.

PMID: 36259473 PMC: 9617020. DOI: 10.22074/cellj.2022.8154.

Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment.

Mafi A, Rahmati A, Babaei Aghdam Z, Salami R, Salami M, Vakili O Cell Mol Biol Lett. 2022; 27(1):65.

PMID: 35922753 PMC: 9347108. DOI: 10.1186/s11658-022-00354-4.

The Use of Pro-Angiogenic and/or Pro-Hypoxic miRNAs as Tools to Monitor Patients with Diffuse Gliomas.

Levallet G, Dubois F, Leclerc A, Petit E, Bekaert L, Faisant M Int J Mol Sci. 2022; 23(11).

PMID: 35682718 PMC: 9181142. DOI: 10.3390/ijms23116042.

References

Rao J . Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer. 2003; 3(7):489-501. DOI: 10.1038/nrc1121. View

Lehnertz B, Ueda Y, Derijck A, Braunschweig U, Perez-Burgos L, Kubicek S . Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003; 13(14):1192-200. DOI: 10.1016/s0960-9822(03)00432-9. View

WEINHOUSE S . The Warburg hypothesis fifty years later. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976; 87(2):115-26. DOI: 10.1007/BF00284370. View

Gatenby R, Gillies R . Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004; 4(11):891-9. DOI: 10.1038/nrc1478. View

Rong Y, Durden D, Van Meir E, Brat D . 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol. 2006; 65(6):529-39. DOI: 10.1097/00005072-200606000-00001. View

Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, Meister M . The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res. 2007; 67(4):1419-23. DOI: 10.1158/0008-5472.CAN-06-4074. View

Louis D, Ohgaki H, Wiestler O, Cavenee W, Burger P, Jouvet A . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007; 114(2):97-109. PMC: 1929165. DOI: 10.1007/s00401-007-0243-4. View

Jain R, Tomaso E, Duda D, Loeffler J, Sorensen A, Batchelor T . Angiogenesis in brain tumours. Nat Rev Neurosci. 2007; 8(8):610-22. DOI: 10.1038/nrn2175. View

Orom U, Nielsen F, Lund A . MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell. 2008; 30(4):460-71. DOI: 10.1016/j.molcel.2008.05.001. View

10.

Gabriely G, Wurdinger T, Kesari S, Esau C, Burchard J, Linsley P . MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008; 28(17):5369-80. PMC: 2519720. DOI: 10.1128/MCB.00479-08. View

11.

Parsons D, Jones S, Zhang X, Cheng-Ho Lin J, Leary R, Angenendt P . An integrated genomic analysis of human glioblastoma multiforme. Science. 2008; 321(5897):1807-12. PMC: 2820389. DOI: 10.1126/science.1164382. View

12.

Wurdinger T, Tannous B, Saydam O, Skog J, Grau S, Soutschek J . miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell. 2008; 14(5):382-93. PMC: 2597164. DOI: 10.1016/j.ccr.2008.10.005. View

13.

Xia H, Qi Y, Ng S, Chen X, Li D, Chen S . microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res. 2009; 1269:158-65. DOI: 10.1016/j.brainres.2009.02.037. View

14.

Yu B, Zhao X, Lee L, Lee R . Targeted delivery systems for oligonucleotide therapeutics. AAPS J. 2009; 11(1):195-203. PMC: 2664895. DOI: 10.1208/s12248-009-9096-1. View

15.

Sasayama T, Nishihara M, Kondoh T, Hosoda K, Kohmura E . MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer. 2009; 125(6):1407-13. DOI: 10.1002/ijc.24522. View

16.

Silber J, James C, Hodgson J . microRNAs in gliomas: small regulators of a big problem. Neuromolecular Med. 2009; 11(3):208-22. DOI: 10.1007/s12017-009-8087-9. View

17.

Li Y, Guessous F, Zhang Y, diPierro C, Kefas B, Johnson E . MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 2009; 69(19):7569-76. PMC: 2756313. DOI: 10.1158/0008-5472.CAN-09-0529. View

18.

Kefas B, Comeau L, Floyd D, Seleverstov O, Godlewski J, Schmittgen T . The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 2009; 29(48):15161-8. PMC: 2823067. DOI: 10.1523/JNEUROSCI.4966-09.2009. View

19.

Verhaak R, Hoadley K, Purdom E, Wang V, Qi Y, Wilkerson M . Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010; 17(1):98-110. PMC: 2818769. DOI: 10.1016/j.ccr.2009.12.020. View

20.

Godlewski J, Nowicki M, Bronisz A, Nuovo G, Palatini J, De Lay M . MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010; 37(5):620-32. PMC: 3125113. DOI: 10.1016/j.molcel.2010.02.018. View