The Inhibitory Effects of Isolated Constituents from Subsp. L. on Collagenase, Elastase and Hyaluronidase Enzymes: Potential Wound Healer

Overview

Journal Saudi Pharm J

Specialty Pharmacy

Date 2020 Jan 11

PMID 31920436

Citations 11

Authors

Yasin Genc

Fatma Tugce Guragac Dereli

Iclal Saracoglu

Esra Kupeli Akkol

Affiliations

Soon will be listed here.

Abstract

L. which is a medicinal plant with important biological activities, commonly used as traditional medicine. Potential inhibitory activities of the aqueous extract and three isolated constituents calceorioside B (), homoplantaginin (hispidulin-7-O-glucoside) () and plantamajoside () from the aerial parts of subsp. L. (Plantaginaceae) have been tested against hyaluronidase, collagenase, and elastase, which play critical roles in wound pathogenesis. Even though, the extract (27.04%), and among the isolated compounds, calceorioside B (41.16%) exerted significant inhibition against hyaluronidase enzyme, homoplantaginin and plantamajoside were found to be inactive. Similar results were obtained from collagenase enzyme inhibition test. The extract (21.92%) and calceorioside B (28.34%) also caused notable inhibition in this test. However, no remarkable inhibition was observed in the presence of elastase enzyme. The experimental data revealed that subsp. displayed remarkable inhibitory activity against hyaluronidase and collagenase enzymes. enzyme activity of subsp. is reported for the first time in the current study.

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