Preservation of Post-Infarction Cardiac Structure and Function Via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

Overview

Journal JACC Basic Transl Sci

Date 2020 Jan 8

PMID 31909300

Citations 16

Authors

Ricardo A Garcia

Bruce R Ito

John A Lupisella

Nancy A Carson

Mei-Yin Hsu

Gayani Fernando

Madeleine Heroux

Michel Bouvier

Elizabeth Dierks

Ellen K Kick

David A Gordon

Jian Chen

Gabe Mintier

Marilyn Carrier

Stephane St-Onge

Himanshu Shah

Jordan Towne

Marcela Sotelo Bucardo

Xiuying Ma

Carol S Ryan

Nicholas R Wurtz

Jacek Ostrowski

Francisco J Villarreal

Affiliations

Soon will be listed here.

Abstract

Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and progression towards heart failure. This study characterized the cellular and signaling properties of Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, and examined whether Cmpd43 treatment improves LV and infarct remodeling in rodent MI models. Cmpd43 stimulated FPR1/2-mediated signaling, enhanced proresolution cellular function, and modulated cytokines. Cmpd43 increased LV function and reduced chamber remodeling while increasing proresolution macrophage markers. The findings demonstrate that FPR agonism improves cardiac structure and function post-MI.

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