Severe Fever with Thrombocytopenia Syndrome Virus Targets B Cells in Lethal Human Infections

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2020 Jan 7

PMID 31904586

Citations 40

Authors

Tadaki Suzuki

Yuko Sato

Kaori Sano

Takeshi Arashiro

Harutaka Katano

Noriko Nakajima

Masayuki Shimojima

Michiyo Kataoka

Kenta Takahashi

Yuji Wada

Shigeru Morikawa

Shuetsu Fukushi

Tomoki Yoshikawa

Masayuki Saijo

Hideki Hasegawa

Affiliations

Soon will be listed here.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne banyangvirus and is associated with high fatality. Despite increasing incidence of SFTS and serious public health concerns in East Asia, the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully understood. Numbers of postmortem examinations to determine target cells of the viral infection have so far been limited. Here we showed that B cells differentiating into plasmablasts and macrophages in secondary lymphoid organs were targets for SFTSV at the end stage of lethal infection, and the majority of SFTSV-infected cells were B cell-lineage lymphocytes. In affected individuals, B cell-lineage lymphocytes with SFTSV infection were widely distributed in both lymphoid and nonlymphoid organs, and infiltration of these cells into the capillaries of the organs could be observed occasionally. Moreover, a human plasmablastic lymphoma cell line, PBL-1, was susceptible to SFTSV propagation and had a similar immunophenotype to that of target cells of SFTSV in fatal SFTS. PBL-1 can therefore provide a potential in vitro model for human SFTSV infection. These results extend our understanding of the pathogenesis of human lethal SFTSV infection and can facilitate the development of SFTSV countermeasures.

Citing Articles

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Limitations of a proper SFTSV mouse model using human C-type lectin receptors.

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The role of blood cell morphology in understanding and diagnosing severe fever with thrombocytopenia syndrome (SFTS): Insights from a case report.

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N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses.

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