Effects of Cinnamon Supplementation on Expression of Systemic Inflammation Factors, NF-kB and Sirtuin-1 (SIRT1) in Type 2 Diabetes: a Randomized, Double Blind, and Controlled Clinical Trial

Overview

Journal Nutr J

Publisher Biomed Central

Specialty Nutritional Sciences

Date 2020 Jan 6

PMID 31901246

Citations 17

Authors

Mina Davari

Reza Hashemi

Parvin Mirmiran

Mehdi Hedayati

Shamim Sahranavard

Shohreh Bahreini

Rahele Tavakoly

Behrouz Talaei

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of three-gram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients.

Subjects And Methods: A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70 years old with type 2 diabetes, randomized to two intervention (n = 22) and control (n = 22) groups differing by daily three grams cinnamon supplementation and placebo for 8 weeks, respectively. The plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α were measured by ELISA assay at the beginning and end of the study.

Results: After 8-week intervention, 39 subjects (n = 20 in the cinnamon and n = 19 in the placebo groups) ended up the trial. It was not observed significant difference in levels of hs-CRP (P = 0.29), TNF-α (P = 0.27), IL-6 (P = 0.52), and Sirtuin-1 (P = 0.51) in between group comparison. While, the result showed significant difference in levels of NF-kB (P = 0.02) between groups. As well as, in among group comparison, there was not observed significant differences except in hs-CRP (P = 0.008) in placebo group.

Conclusions: This study elucidated that cinnamon supplementation has no beneficial effects in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α levels in type 2 diabetes patients which have a considerable role in development of atherogenesis.

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