The Protective Effects of Mogroside V and Its Metabolite 11-oxo-mogrol of Intestinal Microbiota Against MK801-induced Neuronal Damages

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2020 Jan 5

PMID 31900523

Citations 14

Authors

Peijun Ju

Wenhua Ding

Jianhua Chen

Ying Cheng

Beibei Yang

Lanting Huang

Qiong Zhou

Cuizhen Zhu

Xiaobo Li

Mengyue Wang

Jinghong Chen

Affiliations

Soon will be listed here.

Abstract

Rationale: Animal models, notably with non-competitive NMDA receptor antagonist MK801, are commonly used to investigate the mechanisms of schizophrenia and to pursue its mechanism-related drug discoveries.

Objectives: In the current study, we have extensively examined the protective effects of MogrosideV (MogV), a plant-derived three terpene glucoside known to exhibit anti-oxidative and anti-inflammatory activities.

Methods And Results: Here, we investigated its protective effects against neuronal damages elicited by MK-801 treatment. Our behavioral experimental results showed that MK-801-induced PPI deficits and social withdrawal were prevented by MogV treatment. Moreover, the cellular and neurochemical responses of MK-801 in medial prefrontal cortical cortex (mPFC) were also ameliorated by MogV treatment. Also, profiling metabolites assay through artificial intestinal microbiota was performed to identify bioactive components of MogV. An in vitro study of primary neuronal culture demonstrated that MogV and its metabolite 11-oxo-mogrol treatment prevented the MK-801-induced neuronal damages through the mechanisms of promoting neurite outgrowth, inhibiting cell apoptosis, and [Ca] release. Additionally, 11-oxo-mogrol reversed inactivation of phosphorylation levels of AKT and mTOR induced by MK801.

Conclusions: These results suggest therapeutic potential of MogV for schizophrenia.

Citing Articles

Mogrol Regulates the Expression of ATPase Na+/K+ Transport Subunit 3, Inhibits Cardiomyocyte Apoptosis, and Plays a Protective Role Against Myocardial Infarction.

Wang F, Zhou J, Liu W, Wang W, Tian B, Liu J Drug Des Devel Ther. 2025; 19:1489-1502.

PMID: 40051467 PMC: 11884411. DOI: 10.2147/DDDT.S490484.

Medicinal plants and plant-based traditional medicine: Alternative treatments for depression and their potential mechanisms of action.

Remali J, Aizat W Heliyon. 2024; 10(20):e38986.

PMID: 39640650 PMC: 11620067. DOI: 10.1016/j.heliyon.2024.e38986.

Mogroside V and mogrol: unveiling the neuroprotective and metabolic regulatory roles of in Parkinson's disease.

Tang Q, Qiu R, Guo M, Wang L, Zhang Y, Chen Y Front Pharmacol. 2024; 15:1413520.

PMID: 39108761 PMC: 11300226. DOI: 10.3389/fphar.2024.1413520.

Recent Advances in the Distribution, Chemical Composition, Health Benefits, and Application of the Fruit of .

Guo Q, Shi M, Sarengaowa , Xiao Z, Xiao Y, Feng K Foods. 2024; 13(14).

PMID: 39063362 PMC: 11275593. DOI: 10.3390/foods13142278.

A comprehensive review of (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications.

Huang H, Peng Z, Zhan S, Li W, Liu D, Huang S Front Pharmacol. 2024; 15:1388747.

PMID: 38638866 PMC: 11024725. DOI: 10.3389/fphar.2024.1388747.

References

Lin C . Four equivalent sets of mixed-model equations with relationship matrix for estimation of genetic parameters. J Anim Sci. 1988; 66(7):1627-35. DOI: 10.2527/jas1988.6671627x. View

Paulin L, Leheup B, Gueguen R, Deschamps J, PIERSON M . [Evaluation of short stature in boys: delayed growth or constitutional short size?]. Pediatrie. 1989; 44(6):449-54. View

Tambourin P, Casadevall N, Choppin J, Lacombe C, Heard J, Fichelson S . Production of erythropoietin-like activity by a murine erythroleukemia cell line. Proc Natl Acad Sci U S A. 1983; 80(20):6269-73. PMC: 394277. DOI: 10.1073/pnas.80.20.6269. View

. British Society of Digestive Endoscopy. Br Med J. 1971; 4(5782):252. PMC: 1799540. View

Muro T, Yuki H, Kawakita T, Chihara Y, Yasumoto M, Setoguchi S . [Syntheses and pharmacological activities of 2-(substituted phenoxymethyl)morpholine derivatives]. Yakugaku Zasshi. 1986; 106(9):764-74. DOI: 10.1248/yakushi1947.106.9_764. View

Kim S, Park H, Kim H, Ahn Y, Kim Y . Effects of neonatal MK-801 treatment on p70S6K-S6/eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain. Int J Neuropsychopharmacol. 2010; 13(9):1233-46. DOI: 10.1017/S1461145709991192. View

Kwon C, Luikart B, Powell C, Zhou J, Matheny S, Zhang W . Pten regulates neuronal arborization and social interaction in mice. Neuron. 2006; 50(3):377-88. PMC: 3902853. DOI: 10.1016/j.neuron.2006.03.023. View

Li Y, Zou L, Li T, Lai D, Wu Y, Qin S . Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells. Acta Biochim Biophys Sin (Shanghai). 2019; 51(4):365-374. DOI: 10.1093/abbs/gmz014. View

Lim A, Taylor D, Malone D . Consequences of early life MK-801 administration: long-term behavioural effects and relevance to schizophrenia research. Behav Brain Res. 2011; 227(1):276-86. DOI: 10.1016/j.bbr.2011.10.052. View

10.

Maas D, Valles A, Martens G . Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia. Transl Psychiatry. 2017; 7(7):e1171. PMC: 5538118. DOI: 10.1038/tp.2017.138. View

11.

Moghaddam B, Adams B, Verma A, Daly D . Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997; 17(8):2921-7. PMC: 6573099. View

12.

Ichimaru Y, Kodama Y, Ichimaru M, Sato Y, YANAGA T . New system for the assessment of autonomic nervous activity during 24-hour period by spectral analysis of the heart rate. Ann Physiol Anthropol. 1987; 6(4):231-8. DOI: 10.2114/ahs1983.6.231. View

13.

Friend R . Sexual identity and human diversity: implications for nursing practice. Holist Nurs Pract. 1987; 1(4):21-41. DOI: 10.1097/00004650-198708000-00006. View

14.

Shi D, Zheng M, Wang Y, Liu C, Chen S . Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice. Pharm Biol. 2014; 52(6):729-34. DOI: 10.3109/13880209.2013.867451. View

15.

Suryavanshi P, Ugale R, Yilmazer-Hanke D, Stairs D, Dravid S . GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. Br J Pharmacol. 2013; 171(3):799-809. PMC: 3969090. DOI: 10.1111/bph.12518. View

16.

Petru E, Lahousen M, Tamussino K, Pickel H, Stettner H . Prognostic implications of residual tumour volume in stage III ovarian cancer patients undergoing adjuvant cytotoxic chemotherapy. Baillieres Clin Obstet Gynaecol. 1989; 3(1):109-17. DOI: 10.1016/s0950-3552(89)80046-x. View

17.

Nordborg C, Conradi N, SOURANDER P, Westerberg B . A new type of non-progressive sensory neuropathy in children with atypical dysautonomia. Acta Neuropathol. 1981; 55(2):135-41. DOI: 10.1007/BF00699238. View

18.

Zhao P . [Determination of indirubin by dual wavelength TLC scanner (author's transl)]. Zhong Yao Tong Bao. 1981; 6(4):28-30. View