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Confounding Effect of Blood Volume and Body Mass Index on Blood Neurofilament Light Chain Levels

Overview
Journal Ann Clin Transl Neurol
Specialty Neurology
Date 2020 Jan 2
PMID 31893563
Citations 108
Authors
Ali Manouchehrinia
Fredrik Piehl
Jan Hillert
Jens Kuhle
Lars Alfredsson
Tomas Olsson
Ingrid Kockum
Affiliations
Soon will be listed here.
Abstract

Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals' Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.

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