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Lars Alfredsson

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Articles 421
Citations 22655
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Recent Articles
1.
Sattarnezhad N, Kockum I, Thomas O, Liu Y, Ho P, Barrett A, et al.
Proc Natl Acad Sci U S A . 2025 Mar; 122(11):e2424986122. PMID: 40063790
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which is linked to Epstein-Barr virus (EBV) infection, preceding the disease. The molecular mechanisms underlying this...
2.
Johansson E, Olsson T, Alfredsson L, Hedstrom A
Eur J Epidemiol . 2025 Mar; PMID: 40038142
Background: Accumulating evidence suggest that Epstein-Barr virus (EBV) is crucial in the development of multiple sclerosis (MS), with inadequate infection control possibly contributing to disease onset. Past infectious mononucleosis (IM)...
3.
Vaivade A, Erngren I, Carlsson H, Freyhult E, Emami Khoonsari P, Noui Y, et al.
Nat Commun . 2025 Feb; 16(1):2014. PMID: 40016224
Exposure to per- and polyfluorinated substances (PFAS) and hydroxylated polychlorinated biphenyls (OH-PCBs) is associated with adverse human health effects, including immunosuppression. It is unknown if these substances can affect the...
4.
Johansson E, Guo J, Wu J, Olsson T, Alfredsson L, Hedstrom A
J Neurol Neurosurg Psychiatry . 2025 Feb; PMID: 40000244
Background: Emerging evidence indicates that diet, including fish consumption, may play a role in the development and progression of multiple sclerosis (MS). We aimed to investigate the influence of fish...
5.
Guo J, Olsson T, Hillert J, Alfredsson L, Hedstrom A
J Neurol Neurosurg Psychiatry . 2025 Feb; PMID: 39947886
Background: Benign multiple sclerosis (MS), characterised by minimal disability despite long disease duration, remains poorly understood in terms of its determinants and prognostic implications. While lifestyle factors have been implicated...
6.
Nyberg S, Frank P, Pentti J, Alfredsson L, Ervasti J, Goldberg M, et al.
Lancet Public Health . 2025 Feb; 10(2):e124-e135. PMID: 39909687
Background: Regular physical activity is recommended for all aged 5 years and older, but the health benefits gained might differ across population subgroups. The aim of this study was to...
7.
Eva J, Olsson T, Alfredsson L, Hedstrom A
Eur J Neurol . 2025 Feb; 32(2):e70058. PMID: 39905709
Background: Smoking and obesity interact to exacerbate the risk of hypertension, diabetes, and cardiovascular disease, but their potential synergistic effects on outcomes in multiple sclerosis (MS) have not been well...
8.
OConnell K, Koromina M, van der Veen T, Boltz T, David F, Yang J, et al.
Nature . 2025 Jan; PMID: 39843750
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants...
9.
Ellegaard M, Ebenesersdottir S, Moore K, Petersen A, Vagene A, Bieker V, et al.
iScience . 2024 Dec; 27(11):111076. PMID: 39620136
The potential of ancient DNA analyses to provide independent sources of information about events in the historical record remains to be demonstrated. Here we apply palaeogenomic analysis to human remains...
10.
Lagutkin D, Panaifo L, Nurul-Aain A, Israelsson L, Hansson M, Lundberg K, et al.
ACR Open Rheumatol . 2024 Nov; 7(1):e11767. PMID: 39576054
Objective: Autoantibodies serve as essential clinical biomarkers and may indicate etiological mechanisms in rheumatic diseases. In light of the increasing knowledge concerning the diversity and biologic implications of anti-citrullinated peptide/protein...