Xanthones Protects Lead-induced Chronic Kidney Disease (CKD) Via Activating Nrf-2 and Modulating NF-kB, MAPK Pathway

Overview

Journal Biochem Biophys Rep

Specialty Biochemistry

Date 2019 Dec 31

PMID 31886417

Citations 12

Authors

Mohammad Nasiruddin Rana

Jitbanjong Tangpong

Md Atiar Rahman

Affiliations

Soon will be listed here.

Abstract

Xanthones from a tropical fruit of L. is known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti-bacterial, anti-inflammatory, and antidiabetic activities. The current study aimed to assess the possible protective effects of xanthones against lead acetate (PbAc)-induced chronic kidney disease (CKD). To accomplish, antioxidant assays of xanthones, oxidative stress parameters, histopathology, inflammatory parameters were evaluated using PbAc-induced IRC male mice. The study was supported by molecular docking of respective organ receptor protein-ligand interaction. Results revealed that xanthones potentially scavenged the DPPH, superoxide, hydroxyl, and nitric oxide radicals. Oxidative stress, kidney dysfunction, inflammatory markers, and kidney apoptosis increased by PbAc were attenuated with the co-treatment of xanthones. The treatment remarkably improved the tissue architecture. Of note, prediction of activity study showed that protective role of xanthones could be due to its efficacy to activate the Nrf-2, regulate the intracellular [Ca], as well as downregulate the NF-kB, MAPK pathway. In a nutshell, xanthones could be a potential candidate for the management of PbAc-induced kidney damage.

Citing Articles

Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review.

Suhandi C, Wilar G, Narsa A, Mohammed A, El-Rayyes A, Muchtaridi M Drug Des Devel Ther. 2024; 18:4723-4748.

PMID: 39469723 PMC: 11514645. DOI: 10.2147/DDDT.S478388.

Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.

Simsek H, Kucukler S, Gur C, Ileriturk M, Aygormez S, Kandemir F Iran J Basic Med Sci. 2023; 26(9):1098-1106.

PMID: 37605724 PMC: 10440130. DOI: 10.22038/IJBMS.2023.71905.15623.

Antidotal and protective effects of mangosteen () against natural and chemical toxicities: A review.

Zonouz A, Rahbardar M, Hosseinzadeh H Iran J Basic Med Sci. 2023; 26(5):492-503.

PMID: 37051107 PMC: 10083825. DOI: 10.22038/IJBMS.2023.66900.14674.

Mangosteen vinegar from Garcinia mangostana: quality improvement and antioxidant properties.

Suksamran N, Anantawat V, Wattanaarsakit P, Wei C, Rahman M, Majima H Heliyon. 2023; 8(12):e11943.

PMID: 36590574 PMC: 9800291. DOI: 10.1016/j.heliyon.2022.e11943.

Peptides GWN and GW protect kidney cells against Dasatinib induced mitochondrial injury in a SIRT1 dependent manner.

Bhullar K, Ashkar F, Wu J Food Chem (Oxf). 2022; 4:100069.

PMID: 35415678 PMC: 8991994. DOI: 10.1016/j.fochms.2021.100069.

References

Weydert C, Cullen J . Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. 2010; 5(1):51-66. PMC: 2830880. DOI: 10.1038/nprot.2009.197. View

Uddin M, Reza A, Abdullah-Al-Mamun M, Kabir M, Nasrin M, Akhter S . Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of : An Experimental Assessment in Mice and Computer Aided Models. Front Pharmacol. 2018; 9:246. PMC: 5907530. DOI: 10.3389/fphar.2018.00246. View

Nair M, Mahajan S, Reynolds J, Aalinkeel R, Nair H, Schwartz S . The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol. 2006; 13(3):319-28. PMC: 1391952. DOI: 10.1128/CVI.13.3.319-328.2006. View

Reckziegel P, Dias V, Benvegnu D, Boufleur N, Barcelos R, Segat H . Antioxidant protection of gallic acid against toxicity induced by Pb in blood, liver and kidney of rats. Toxicol Rep. 2017; 3:351-356. PMC: 5615824. DOI: 10.1016/j.toxrep.2016.02.005. View

Karim N, Rahman A, Chanudom L, Thongsom M, Tangpong J . Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis. J Food Sci. 2019; 84(5):1208-1215. DOI: 10.1111/1750-3841.14511. View

Tangpong J, Satarug S . Alleviation of lead poisoning in the brain with aqueous leaf extract of the Thunbergia laurifolia (Linn.). Toxicol Lett. 2010; 198(1):83-8. DOI: 10.1016/j.toxlet.2010.04.031. View

Taher M, Tg Zakaria T, Susanti D, Zakaria Z . Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2016; 16:135. PMC: 4875614. DOI: 10.1186/s12906-016-1118-9. View

Yadav S, Adhikary B, Chand S, Maity B, Bandyopadhyay S, Chattopadhyay S . Molecular mechanism of indomethacin-induced gastropathy. Free Radic Biol Med. 2012; 52(7):1175-87. DOI: 10.1016/j.freeradbiomed.2011.12.023. View

Hill N, Fatoba S, Oke J, Hirst J, OCallaghan C, Lasserson D . Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis. PLoS One. 2016; 11(7):e0158765. PMC: 4934905. DOI: 10.1371/journal.pone.0158765. View

10.

Gulcin I . The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int J Food Sci Nutr. 2006; 56(7):491-9. DOI: 10.1080/09637480500450248. View

11.

Basalamah M, Abdelghany A, El-Boshy M, Ahmad J, Idris S, Refaat B . Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats. Sci Rep. 2018; 8(1):4853. PMC: 5859277. DOI: 10.1038/s41598-018-23258-w. View

12.

Dkhil M, Al-Khalifa M, Al-Quraishy S, Zrieq R, Abdel Moneim A . Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model. Drug Des Devel Ther. 2016; 10:1847-56. PMC: 4898036. DOI: 10.2147/DDDT.S105511. View

13.

Marklund S, Marklund G . Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974; 47(3):469-74. DOI: 10.1111/j.1432-1033.1974.tb03714.x. View

14.

Antonio-Garcia M, Masso-Gonzalez E . Toxic effects of perinatal lead exposure on the brain of rats: involvement of oxidative stress and the beneficial role of antioxidants. Food Chem Toxicol. 2008; 46(6):2089-95. DOI: 10.1016/j.fct.2008.01.053. View

15.

Tong S, Von Schirnding Y, Prapamontol T . Environmental lead exposure: a public health problem of global dimensions. Bull World Health Organ. 2000; 78(9):1068-77. PMC: 2560844. View

16.

Wang A, Liu Q, Ye Y, Wang Y, Lin L . Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells. Food Funct. 2015; 6(9):3013-21. DOI: 10.1039/c5fo00573f. View

17.

Leff T, Stemmer P, Tyrrell J, Jog R . Diabetes and Exposure to Environmental Lead (Pb). Toxics. 2018; 6(3). PMC: 6161143. DOI: 10.3390/toxics6030054. View

18.

Jayasumana C, Gunatilake S, Siribaddana S . Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy. BMC Nephrol. 2015; 16:103. PMC: 4499177. DOI: 10.1186/s12882-015-0109-2. View

19.

Muntner P, He J, Vupputuri S, Coresh J, Batuman V . Blood lead and chronic kidney disease in the general United States population: results from NHANES III. Kidney Int. 2003; 63(3):1044-50. DOI: 10.1046/j.1523-1755.2003.00812.x. View

20.

Zhao H, Jiang Z, Chang X, Xue H, Yahefu W, Zhang X . 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice. Front Pharmacol. 2018; 9:653. PMC: 6020787. DOI: 10.3389/fphar.2018.00653. View