Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2019 Dec 31

PMID 31885630

Citations 54

Authors

Yun-Xia Zhao

Shao-Rong Chen

Ping-Ping Su

Feng-Huang Huang

Yan-Chuan Shi

Qi-Yang Shi

Shu Lin

Affiliations

Soon will be listed here.

Abstract

Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational medicine has developed rapidly, and clinical researchers are focusing on the treatment of female infertility using novel approaches. Owing to the advantages of convenient samples, abundant sources, and avoidable ethical issues, mesenchymal stem cells (MSCs) can be applied widely in the clinic. This paper reviews recent advances in using four types of MSCs, bone marrow stromal cells, adipose-derived stem cells, menstrual blood mesenchymal stem cells, and umbilical cord mesenchymal stem cells. Each of these have been used for the treatment of ovarian and uterine diseases, and provide new approaches for the treatment of female infertility.

Citing Articles

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Advances in Mesenchymal Stem Cell Research Applications for Female Infertility-Mechanisms, Efficacy Parameters, Challenges and Future Roadmap.

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Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results.

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Functional variation among mesenchymal stem cells derived from different tissue sources.

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