Detection of Novel Orthoreovirus Genomes in Shrew (Crocidura Hirta) and Fruit Bat (Rousettus Aegyptiacus)

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2019 Dec 24

PMID 31866632

Citations 3

Authors

Hayato Harima

Michihito Sasaki

Masahiro Kajihara

Akina Mori-Kajihara

Bernard M Hangombe

Katendi Changula

Yasuko Orba

Hirohito Ogawa

Martin Simuunza

Reiko Yoshida

Aaron Mweene

Ayato Takada

Hirofumi Sawa

Affiliations

Soon will be listed here.

Abstract

Orthoreoviruses have been indentified in several mammals, however, there is no information about orthoreoviruses in shrews. In this study, we screened wild animals in Zambia, including shrews, rodents, and bats for the detection of orthoreoviruses. Two orthoreovirus RNA genomes were detected from a shrew intestinal-contents (1/24) and a bat colon (1/96) sample by reverse-transcription (RT)-PCR targeting the RNA-dependent RNA polymerase gene of orthoreoviruses. Phylogenetic analyses revealed that each of the identified orthoreoviruses formed a distinct branch among members of the Orthoreovirus genus. This is the first report that shrews are susceptible to orthoreovirus infection. Our results suggest the existence of undiscovered orthoreoviruses in shrews and provide important information about the genetic diversity of orthoreoviruses.

Citing Articles

Unveiling the hidden threats: a review of pathogen diversity and public health risks from bats, rodents, and non-human primates in Zambia (1990-2022).

Munjita S, Mubemba B, Changula K, Tembo J, Hamoonga R, Bates M Front Public Health. 2024; 12:1471452.

PMID: 39651468 PMC: 11621629. DOI: 10.3389/fpubh.2024.1471452.

Revising the paradigm: Are bats really pathogen reservoirs or do they possess an efficient immune system?.

Weinberg M, Yovel Y iScience. 2022; 25(8):104782.

PMID: 35982789 PMC: 9379578. DOI: 10.1016/j.isci.2022.104782.

Attenuated infection by a Pteropine orthoreovirus isolated from an Egyptian fruit bat in Zambia.

Harima H, Sasaki M, Orba Y, Okuya K, Qiu Y, Wastika C PLoS Negl Trop Dis. 2021; 15(9):e0009768.

PMID: 34492038 PMC: 8448348. DOI: 10.1371/journal.pntd.0009768.

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