Characterization of a Novel Orthoreovirus Isolated from Fruit Bat, China

Overview

Journal BMC Microbiol

Publisher Biomed Central

Specialty Microbiology

Date 2014 Dec 1

PMID 25433675

Citations 26

Authors

Tingsong Hu

Wei Qiu

Biao He

Yan Zhang

Jing Yu

Xiu Liang

Wendong Zhang

Gang Chen

Yingguo Zhang

Yiyin Wang

Ying Zheng

Ziliang Feng

Yonghe Hu

Weiguo Zhou

Changchun Tu

Quanshui Fan

Fuqiang Zhang

Affiliations

Soon will be listed here.

Abstract

Background: In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin.

Results: In this report, we isolated a novel Melaka-like reovirus (named "Cangyuan virus") from intestinal content samples of one fruit bat residing in China's Yunnan province. Phylogenetic analysis of the whole Cangyuan virus genome sequences of segments L, M and S demonstrated the genetic diversity of the Cangyuan virus. In contrast to the L and M segments, the phylogenetic trees for the S segments of Cangyuan virus demonstrated a greater degree of heterogeneity.

Conclusions: Phylogenetic analysis indicated that the Cangyuan virus was a novel orthoreovirus and substantially different from currently known members of Pteropine orthoreovirus (PRV) species group.

Citing Articles

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Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor.

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Nouda R, Kawagishi T, Kanai Y, Shimojima M, Saijo M, Matsuura Y PLoS Pathog. 2022; 18(6):e1010553.

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Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M Int J Mol Sci. 2021; 22(19).

PMID: 34639103 PMC: 8509532. DOI: 10.3390/ijms221910763.

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