» Articles » PMID: 31858420

Proposal of Hemodynamically Improved Design of an Axial Flow Blood Pump for LVAD

Overview
Publisher Springer
Date 2019 Dec 21
PMID 31858420
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Left ventricular assist devices (LVAD) emerges as an effective clinical device providing life-saving support to heart patients. The design of blood pump of an LVAD involves incredible accuracy and thorough understanding of hemodynamics to mimic the functionality of a healthy ventricle. This work studies hemodynamics around an LVAD and proposes an improved model of axial blood pump for cardiac circulation without any hemolysis complications through numerical investigations. A three-dimensional study on different versions of the impeller with three curved blades (pump I) and spiral blade (pump II) is carried out by utilizing computational fluid dynamics software ANSYS-CFX at a range of rotational speeds and flow rates. The non-Newtonian blood flow through pump is modeled by using Bird-Carreau model. To capture the change in the flow field near the rotating blade, a transient blade row model was employed. The proposal of spiral blade impeller was found to be more compatible as per the hemolytic performance. It considerably reduces the blood damage to two times lesser value than that by pump I and also improves the quality blood flow field. The spiral blade provides a guiding path to the blood particle and avoids mixing of different bloodstreams, thus reducing the eddy losses. Graphical abstract The graphical abstract shows the performance enhancement of the axial blood pump. The model proposed by Peng et al. (Comput Methods Biomech Biomed Engin 17(7):723-727, 2014) has been upgraded to two new versions by redesigning its impeller. Proposed design (pump II) shows improvement in pressure distribution (a) and reduction in hemolysis (in the case of pump II) index (b).

Citing Articles

Optimizing the design of a pediatric blood pump through orthogonal experimentation.

Gu K, Yang K, Zhao C, Shu Q, Lin R Heliyon. 2025; 11(4):e42502.

PMID: 40051846 PMC: 11883357. DOI: 10.1016/j.heliyon.2025.e42502.


Analysis of fluid forces impacting on the impeller of a mixed flow blood pump with computational fluid dynamics.

Diallo A, Cinar H, Yapici R Int J Artif Organs. 2024; 47(12):894-907.

PMID: 39511833 PMC: 11613519. DOI: 10.1177/03913988241293003.


Machine learning based on computational fluid dynamics enables geometric design optimisation of the NeoVAD blades.

Nissim L, Karnik S, Smith P, Wang Y, Frazier O, Fraser K Sci Rep. 2023; 13(1):7183.

PMID: 37137928 PMC: 10156814. DOI: 10.1038/s41598-023-33708-9.


Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.

Romanova A, Pugovkin A, Denisov M, Ephimov I, Gusev D, Walter M J Funct Biomater. 2022; 13(1).

PMID: 35076513 PMC: 8788462. DOI: 10.3390/jfb13010007.

References
1.
Anderson J, Wood H, Allaire P, McDaniel J, Olsen D, Bearnson G . Numerical studies of blood shear and washing in a continuous flow ventricular assist device. ASAIO J. 2000; 46(4):486-94. DOI: 10.1097/00002480-200007000-00024. View

2.
Slaughter M, Rogers J, Milano C, Russell S, Conte J, Feldman D . Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009; 361(23):2241-51. DOI: 10.1056/NEJMoa0909938. View

3.
Taskin M, Fraser K, Zhang T, Gellman B, Fleischli A, Dasse K . Computational characterization of flow and hemolytic performance of the UltraMag blood pump for circulatory support. Artif Organs. 2010; 34(12):1099-113. DOI: 10.1111/j.1525-1594.2010.01017.x. View

4.
Leverett L, Hellums J, ALFREY C, Lynch E . Red blood cell damage by shear stress. Biophys J. 1972; 12(3):257-73. PMC: 1484094. DOI: 10.1016/S0006-3495(72)86085-5. View

5.
Shibeshi S, Collins W . The Rheology of Blood Flow in a Branched Arterial System. Appl Rheol. 2006; 15(6):398-405. PMC: 1552100. DOI: 10.1901/jaba.2005.15-398. View