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Plasmodium Chabaudi Malaria: Protective Immunization with Surface Membranes of Infected Erythrocytes

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1988 Dec 1
PMID 3182084
Citations 19
Authors
F Wunderlich
H H BRENNER
M Helwig
Affiliations
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Abstract

Plasmodium chabaudi-susceptible NMRI and B10.A mice were vaccinated with host cell plasma membranes isolated from P. chabaudi-infected erythrocytes. Most of the mice were protected from the lethal consequences of challenge with the homologous parasite, although protection was unassociated with a reduction in the course or peak of parasitemia. Vaccination also induced the production of antibodies against Pc90, which is the immunodominant protein expressed by parasites in host cell plasma membranes.

Citing Articles

Vaccination Accelerates Liver-Intrinsic Expression of Megakaryocyte-Related Genes in Response to Blood-Stage Malaria.

Wunderlich F, Delic D, Gerovska D, Arauzo-Bravo M Vaccines (Basel). 2022; 10(2).

PMID: 35214745 PMC: 8880532. DOI: 10.3390/vaccines10020287.

Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells.

Arauzo-Bravo M, Delic D, Gerovska D, Wunderlich F Vaccines (Basel). 2020; 8(4).

PMID: 33202767 PMC: 7712122. DOI: 10.3390/vaccines8040677.

Protective Immunity in Mice Immunized With MSP1-Based Formulations and Challenged With Expressing MSP1.

Dobrescu I, de Camargo T, Gimenez A, Murillo O, Amorim K, Marinho C Front Immunol. 2020; 11:28.

PMID: 32153555 PMC: 7045055. DOI: 10.3389/fimmu.2020.00028.

Vaccination accelerates hepatic erythroblastosis induced by blood-stage malaria.

Delic D, Wunderlich F, Al-Quraishy S, Abdel-Baki A, Dkhil M, Arauzo-Bravo M Malar J. 2020; 19(1):49.

PMID: 31996238 PMC: 6988251. DOI: 10.1186/s12936-020-3130-2.

Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria.

Al-Quraishy S, Dkhil M, Al-Shaebi E, Abdel-Baki A, Arauzo-Bravo M, Delic D Malar J. 2018; 17(1):215.

PMID: 29843710 PMC: 5975554. DOI: 10.1186/s12936-018-2366-6.

References
1.
Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View
2.
Towbin H, Staehelin T, Gordon J . Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979; 76(9):4350-4. PMC: 411572. DOI: 10.1073/pnas.76.9.4350. View
3.
Jensen J, Boland M, Akood M . Induction of crisis forms in cultured Plasmodium falciparum with human immune serum from Sudan. Science. 1982; 216(4551):1230-3. DOI: 10.1126/science.7043736. View
4.
Wunderlich F, Stubig H, Konigk E . Development of Plasmodium chabaudi in mouse red blood cells: structural properties of the host and parasite membranes. J Protozool. 1982; 29(1):60-6. DOI: 10.1111/j.1550-7408.1982.tb02880.x. View
5.
Wunderlich F, Helwig M, Schillinger G, Speth V . Cryptic disposition of antigenic parasite proteins in plasma membranes of erythrocytes infected with Plasmodium chabaudi. Mol Biochem Parasitol. 1988; 30(1):55-65. DOI: 10.1016/0166-6851(88)90132-6. View