Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure

Overview

Journal Cardiovasc Ther

Publisher Hindawi

Date 2019 Dec 11

PMID 31819762

Citations 45

Authors

Qiujin Jia

Hao Li

Huan Zhou

Xiaonan Zhang

Ao Zhang

YingYu Xie

Yanyang Li

Shichao Lv

Junping Zhang

Affiliations

Soon will be listed here.

Abstract

Although the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high. Modern studies have shown that gut microbiota is associated with a variety of cardiovascular diseases, among which the study of gut microbiota and heart failure attracts particular attention. Therefore, understanding the role of gut microbiota in the occurrence and development of heart failure will help us further understand the pathogenesis of heart failure and provide new ideas for its treatment. This paper introduced intestinal flora and its metabolites, summarized the changes of intestinal flora in patients with heart failure, clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure. At the same time, regulating intestinal microflora through diet, probiotics, antibiotics, fecal transplantation and microbial enzyme inhibitors has grown up to be a potential treatment for many metabolic disorders.

Citing Articles

Evaluation value of ultrasound on gastrointestinal function in patients with acute heart failure.

Hao R, Zheng Y, Zhao Q, Chen J, Fan R, Chen P Front Cardiovasc Med. 2024; 11:1475920.

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The Bidirectional Relationship Between Cardiovascular Medications and Oral and Gut Microbiome Health: A Comprehensive Review.

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Role of Trimethylamine N-Oxide in Heart Failure.

Jing L, Zhang H, Xiang Q, Hu H, Zhai C, Xu S Rev Cardiovasc Med. 2024; 25(7):240.

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